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AdipoGen Life Sciences
Rifamycin AF-O13
150
CHF
CHF 150.00
In stock
AG-CN2-0336-M01010 mgCHF 150.00
AG-CN2-0336-M05050 mgCHF 600.00
| Product Details | |
|---|---|
| Synonyms | 3-Formylrifamycin SV O-n-octyloxime; 3- Formylrifamycin SV O-octyloxime; AF 013; NCI 143-483; NSC 143483; Rifampicin AF 013; Rifamycin AF 013 |
| Product Type | Chemical |
| Properties | |
| Formula |
C46H64N2O13 |
| MW | 853.0 |
| CAS | 35225-13-9 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Red powder. |
| Solubility | Soluble in DMSO, aqueous acetonitrile or ethanol. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | DTEDDHSJILGOKQ-RIPXLWFGSA-N |
| Smiles | OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@H]2C)O)=O)C(/C=N/OCCCCCCCC)=C(O)C3=C4C(O[C@@](O/C=C/[C@H](OC)[C@H]([C@H]2OC(C)=O)C)(C)C4=O)=C(C)C(O)=C31 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Ansamycin antibiotic.
- Potent inhibitor of nucleic acid polymerizing enzymes and of some hormone receptors.
- Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
- Inhibitor of RNA-dependent DNA polymerase of MSV.
- Effective against mycobacteria and therefore might be used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Product References
- Reverse transcriptase, RNA tumor virus transformation, and derivatives of rifamycin SV: R.C. Ting, et al.; Nat. New Biol. 236, 163 (1972)
- Selective toxicity of rifamycin derivatives for leukaemic human leucocytes: R.G. Smith, et al.; Nat. New Biol. 236, 1166 (1972)
- Rifamycin antibiotics: inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts: S.S. Yang, et al.; J. Natl. Cancer Inst. 49, 7 (1972)
- Rifamycin Derivatives Strongly Inhibiting RNA>DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses: C. Gurgo, et al.; J. Natl. Cancer Inst. 49, 61 (1972)
- Selective inhibition of Rous sarcoma virus production in transformed chick fibroblasts by two rifamycin derivatives: S. Barlati & P. Vigier; FEBS Lett. 24, 343 (1972)
- Inhibition of RNA polymerases from rat liver by the semi-synthetic rifampicin derivatives: P.P. Juhasz, et al.; FEBS Lett. 27, 30 (1972)
- Mechanism of action of a rifamycin derivative (AF-013) which is active on the nucleic acid polymerases insensitive to rifampicin: S. Riva, et al.; BBRC 49, 1263 (1972)
- Action of rifamycin derivatives on RNA polymerase of human leukemic lymphocytes: M.J. Tsai & G.F. Saunders; PNAS 70, 2072 (1973)
- Activation of DNA polymerase of murine leukemia virus by rifamycin derivatives: S. Barlati, et al.; Intervirol. 2, 33 (1974)
- Specific inhibition of a primer-dependent nucleotide chain elongation reaction by the rifamycin derivative AF/013; S.T. Jacob, et al.; Arch. Biochem. Biophys. 164, 771 (1974)
- Oximes of 3-formylrifamycin SV. Synthesis, antibacterial activity, and other biological properties: R. Cricchio, et al.; J. Med. Chem. 17, 396 (1974)
- The inhibition of nuclear RNA synthesis by the rifampicin derivative AF/013 in living cells: E. Egyhazi; Biochim. Biophys. Acta 378, 205 (1975)
- Mechanism of inhibition of RNA polymerase II and poly(adenylic acid) polymerase by the O-n-octyloxime of 3-formylrifamycin SV: K.M. Rose, et al.; Biochemistry 14, 3598 (1975)
- The rifamycin derivative AF/013 is cytolytic: U. Scheer; Mol. Pharmacol. 11, 883 (1975)
- Differential susceptibility of spleen focus-forming virus and murine leukemia viruses to ansamycin antibiotics: J.S. Horoszewicz, et al.; Antimicrob. Agents Chemother. 12, 4 (1977)
- Different modes of inhibition of purified ribonucleic acid directed deoxyribonucleic acid polymerase of avian myeloblastosis virus by rifamycin SV derivatives: C. Gurgo & D.P.Grandgenett; Biochemistry. 16, 786 (1977)
- Inhibition of DNA polymerases alpha and gamma by rifamycin derivative AF/013: T. Yagura, et al.; J. Biochem. 90, 1397 (1981)
- Inhibitory action of aurintricarboxylic acid and rifamycin AF/013 at the polynucleotide domain of 1,25-dihydroxyvitamin D3-receptor complexes: W.S. Mellon; Biochem. Pharmacol. 33, 1047 (1984)
- Inhibition by rifamycin AF/013 of thyroid hormone binding to the nuclear receptor: A. Inoue, et al.; J. Biochem. 102, 1365 (1987)
- Effects of antibiotics on RNA polymerase III transcription: K. Logan & S. Ackerman; DNA 7, 483 (1988)
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