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AdipoGen Life Sciences
Betulin
60
CHF
CHF 60.00
In stock
AG-CN2-0476-M250250 mgCHF 60.00
AG-CN2-0476-G0011 gCHF 120.00
| Product Details | |
|---|---|
| Synonyms | Betulinol; Trochol; NSC 4644 |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H50O2 |
| MW | 442.7 |
| Merck Index | 14: 1198 |
| CAS | 473-98-3 |
| RTECS | OK5755000 |
| Source/Host Chemicals | Isolated from Betulaceae family tree bark. |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO, DMF or ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | FVWJYYTZTCVBKE-ROUWMTJPSA-N |
| Smiles | [H][C@]12[C@@H](CC[C@]1(CO)CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(C)=C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Specific SREBPs (sterol regulatory element-binding proteins) inhibitor. Inhibits ER-Golgi translocation of SREBPs through binding to SCAP in an INSIG-dependent manner.
- Improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Lowers cholesterol levels through inhibition of SREBP-2 activation. Reduces weight gain and adipose tissue size in vivo. Increases oxygen consumption and energy expenditure. Increases UCP1/2 levels in brown adipose tissue (BAT) after cold stimulation.
- Anticancer compound. Apoptosis inducer. DNA topoisomerase II inhibitor.
- Anti-inflammatory compound. Shown to inhibit LPS-induced NO production through the TLR4/NF-κB signaling pathway.
- Antiviral compound.
Product References
- Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity: S. Wada, et al.; J. Nat. Prod. 64, 1545 (2001)
- The synergistic effects of betulin with acyclovir against herpes simplex viruses: Y. Gong, et al.; Antiviral Res. 64, 127 (2004)
- Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques: J.J. Tang, et al.; Cell Metab. 13, 44 (2011)
- A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products: J.R. Krycer, et al.; Biochem. J. 446, 191 (2012)
- Targeting SREBPs for treatment of the metabolic syndrome: S.M. Soyal, et al.; Trends Pharmacol. Sci. 36, 406 (2015)
- Induction of apoptotic cell death by betulin in multidrug-resistant human renal carcinoma cells: N.H. Yim, et al.; Oncol. Rep. 34, 1058 (2015)
- Comprehensive review on betulin as a potent anticancer agent: S.K. Krol, et al.; Biomed. Res. Int. 2015 (Review)
- Betulin derivatives effectively suppress inflammation in vitro and in vivo: M. Laavola, et al.; J. Nat. Prod. 79, 274 (2016)
- Betulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathway: H. Zhao, et al.; Life Sci. 144, 185 (2016)
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