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AdipoGen Life Sciences
Pepstatin A methyl ester
110
CHF
CHF 110.00
In stock
AG-CP3-7004-M0011 mgCHF 110.00
AG-CP3-7004-M0055 mgCHF 440.00
| Product Details | |
|---|---|
| Synonyms | PME; Pepstatin A-OMe; Procidin S 735M; Pepsin Inhibitor S 735M |
| Product Type | Chemical |
| Properties | |
| Formula |
C35H65N5O9 |
| MW | 699.9 |
| CAS | 29169-91-3 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (5mg/ml) or warm methanol. |
| Identity | Determined by ES-MS |
| InChi Key | QDSKCDUNZOMSAY-XAFAIMEYSA-N |
| Smiles | O[C@@H](CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(OC)=O)=O)=O)[C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](C(C)C)NC(CC(C)C)=O)=O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable methyl ester derivative of Pepstatin A.
- Potent, non-competitive, transition-state analog inhibitor of γ-secretase.
Product References
- Interaction of human cathepsin D with the inhibitor pepstatin: C.G. Knight & A.J. Barret; Biochem. J. 155, 117 (1976)
- Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines: G. Tian, et al.; J. Biol. Chem. 277, 31499 (2002)
- The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors: G. Tian, et al.; J. Biol. Chem. 278, 28968 (2003)
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