AdipoGen Life Sciences

Bisindolylmaleimide X . hydrochloride

CHF 90.00
In stock
AG-CR1-0113-M0011 mgCHF 90.00
AG-CR1-0113-M0055 mgCHF 270.00
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Product Details
Synonyms Ro 31-8425; BIM X
Product Type Chemical
Properties
Formula

C26H24N4O2 . HCl

MW 424.5 . 36.5
CAS 145317-11-9
131848-97-0 (free base)
Purity Chemicals ≥95% (HPLC)
Appearance Red solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
InChi Key IMBOYWXMTUUYGZ-UHFFFAOYSA-N
Smiles CC(C)(C=C)C12CC3N(C1NC1=C2C=CC=C1)C(=O)C1CC2(C(NC4=C2C=CC=C4)N1C3=O)C(C)(C)C=C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Store solutions at -20°C in the dark.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Selective protein kinase C (PKC) inhibitor [1-3].
  • Inhibits panel of protein kinases (e.g. GSK-3β, CDK2) [3].
  • Inhibits superoxide generation in human neutrophils [1].
Product References
  1. A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli: R.E. Muid, et al.; FEBS Lett. 293, 169 (1991)
  2. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
  3. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)
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