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AdipoGen Life Sciences
Bisindolylmaleimide X . hydrochloride
90
CHF
CHF 90.00
In stock
AG-CR1-0113-M0011 mgCHF 90.00
AG-CR1-0113-M0055 mgCHF 270.00
| Product Details | |
|---|---|
| Synonyms | Ro 31-8425; BIM X |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H24N4O2 . HCl |
| MW | 424.5 . 36.5 |
| CAS |
145317-11-9 131848-97-0 (free base) |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Red solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | IMBOYWXMTUUYGZ-UHFFFAOYSA-N |
| Smiles | CC(C)(C=C)C12CC3N(C1NC1=C2C=CC=C1)C(=O)C1CC2(C(NC4=C2C=CC=C4)N1C3=O)C(C)(C)C=C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective protein kinase C (PKC) inhibitor [1-3].
- Inhibits panel of protein kinases (e.g. GSK-3β, CDK2) [3].
- Inhibits superoxide generation in human neutrophils [1].
Product References
- A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli: R.E. Muid, et al.; FEBS Lett. 293, 169 (1991)
- Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
- Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)
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