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AdipoGen Life Sciences
Bisindolylmaleimide VIII . acetate
60
CHF
CHF 60.00
In stock
AG-CR1-0114-M0011 mgCHF 60.00
AG-CR1-0114-M0055 mgCHF 240.00
| Product Details | |
|---|---|
| Synonyms | Ro 31-7549; BIM VIII |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H22N4O2 . CH3COOH |
| MW | 398.5 . 60.1 |
| CAS | 138516-31-1 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Red powder. |
| Solubility | Soluble in DMSO, methanol or water. Slightly soluble in ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | VEOXVBTXROWDAH-UHFFFAOYSA-N |
| Smiles | CC(O)=O.CN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CN(CCCN)C2=C1C=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective protein kinase C (PKC) inhibitor [1-3].
- Inhibits proliferation of cultured mouse epidermal keratinocytes [4].
- Enhances Fas- and TRAIL-mediated apoptosis [5, 6].
- Inhibits T cell-mediated autoimmune diseases [5].
- Inhibits stimulation of insulin secretion by glucose [8].
- Inhibits panel of protein kinases (e.g. GSK-3β, CDK2) [7].
Product References
- RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages: P. Dieter & E. Fitzke; BBRC 181, 396 (1991)
- Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
- Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction: R.A. Bit, et al.; J. Med. Chem. 36, 21 (1993)
- Effects of the selective protein kinase C inhibitor, Ro 31-7549, on the proliferation of cultured mouse epidermal keratinocytes: W.B. Bollag, et al.; J. Invest. Dermatol. 100, 240 (1993)
- Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases: T. Zhou, et al.; Nat. Med. 5, 42 (1999)
- Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways: T. Ohtsuka & T. Zhou; J. Biol. Chem. 277, 29294 (2002)
- Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)
- Different signaling pathways involved in glucose- and cell swelling-induced insulin secretion by rat pancreatic islets in vitro: Z. Bacova, et al.; Cell Physiol. Biochem. 16, 59 (2005)
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