3-Aminoisobutyric acid

CHF 55.00
In stock
AG-CR1-3596-M250250 mgCHF 55.00
AG-CR1-3596-G0011 gCHF 120.00
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Product Details
Synonyms β-Aminoisobutyric acid; BAIBA; 3-Amino-2-methylpropanoic acid; DL-3-Aminoisobutyric acid; α-Methyl-β-alanine; 3-Aminoisobutanoate; 3-Aminoisobutyrate
Product Type Chemical
Properties
Formula C4H9NO2 . H2O
MW 103.1 . 18.0
CAS 214139-20-5 and 144-90-1 (anhydrous)
Purity Chemicals ≥98% (TLC)
Appearance White solid.
Solubility Soluble in DMSO or water.
InChi Key QCHPKSFMDHPSNR-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Store solutions at -20°C in the dark.
Documents
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Product Specification Sheet
Datasheet Download PDF
  • Catabolite of thymine [1-4].
  • Precursor for 3-Hydroxyisobutyric acid synthesis [3].
  • Small molecule myokine. Browning inducer of white adipose tissue (WAT) into brown adipose tissue (BAT) [9, 10].
  • PGC-1α-mediated and exercise-triggered nonadrenergic activator of the thermogenic program in WAT. Increases the expression of brown adipocyte-specific genes (browning) in white adipocytes and β-oxidation in hepatocytes through a PPARα-mediated mechanism [9, 10].
  • Induces a brown adipose-like phenotype in human pluripotent stem cells and improves glucose homeostasis [9, 10].
  • Enhances fatty acid oxidation and reduces body weight in mice through an increased production of leptin by the white adipose tissue (WAT) [5-7].
  • Inhibits Agxt2-mediated metabolism of dimethylarginines [8].
  • Partial agonist of the glycine receptor (GlyR) [4].
Product References
  1. beta-Aminoisobutyric acid (alpha-methyl-beta-alanine); a new amino-acid obtained from human urine: H.R. Crumpler, et al.; Nature 167, 307 (1951)
  2. beta-aminoisobutyric acid, a new probe for the metabolism of DNA and RNA in normal and tumorous tissue: H.R. Nielsen, et al.; Cancer Res. 34, 1381 (1974)
  3. Metabolism of thymine in tumor tissue: the origins of beta-aminoisobutyric acid: B.S. Baliga & E. Borek; Adv. Enzyme Regul. 13, 27 (1975)
    Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis: S. Landaas; Clin. Chim. Acta 64, 143 (1975)
  4. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds: V. Schmieden & H. Betz; Mol. Pharmacol. 48, 919 (1995)
  5. Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting: C. Maisonneuve, et al.; Antivir. Ther. 9, 801 (2004)
  6. Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency: K. Begriche, et al.; Obesity (Silver Spring) 16, 2053 (2008)
  7. Effects of beta-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity: K. Begriche, et al.; Fundam. Clin. Pharmacol. 24, 269 (2010)
  8. In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice: A. Kittel, et al.; BBRC 430, 84 (2013)
  9. beta-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors: L.D. Roberts, et al.; Cell Metab. 19, 96 (2014)
  10. Come on BAIBA light my fire: H.L. Kammon & M. Febbraio; Cell Metab. 19, 1 (2014) (Review)
  11. BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice: TW. Jung, et al.; Diabetologia 58, 2096 (2015)
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