AG-CR1-3596-M250250 mgCHF 55.00
AG-CR1-3596-G0011 gCHF 120.00
|Synonyms||β-Aminoisobutyric acid; BAIBA; 3-Amino-2-methylpropanoic acid; DL-3-Aminoisobutyric acid; α-Methyl-β-alanine; 3-Aminoisobutanoate; 3-Aminoisobutyrate|
|Formula||C4H9NO2 . H2O|
|MW||103.1 . 18.0|
|CAS||214139-20-5 and 144-90-1 (anhydrous)|
|Purity Chemicals||≥98% (TLC)|
|Solubility||Soluble in DMSO or water.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Keep cool and dry.|
Stable for at least 2 years after receipt when stored at -20°C.
Store solutions at -20°C in the dark.
|Product Specification Sheet|
- Catabolite of thymine [1-4].
- Precursor for 3-Hydroxyisobutyric acid synthesis .
- Small molecule myokine. Browning inducer of white adipose tissue (WAT) into brown adipose tissue (BAT) [9, 10].
- PGC-1α-mediated and exercise-triggered nonadrenergic activator of the thermogenic program in WAT. Increases the expression of brown adipocyte-specific genes (browning) in white adipocytes and β-oxidation in hepatocytes through a PPARα-mediated mechanism [9, 10].
- Induces a brown adipose-like phenotype in human pluripotent stem cells and improves glucose homeostasis [9, 10].
- Enhances fatty acid oxidation and reduces body weight in mice through an increased production of leptin by the white adipose tissue (WAT) [5-7].
- Inhibits Agxt2-mediated metabolism of dimethylarginines .
- Partial agonist of the glycine receptor (GlyR) .
- beta-Aminoisobutyric acid (alpha-methyl-beta-alanine); a new amino-acid obtained from human urine: H.R. Crumpler, et al.; Nature 167, 307 (1951)
- beta-aminoisobutyric acid, a new probe for the metabolism of DNA and RNA in normal and tumorous tissue: H.R. Nielsen, et al.; Cancer Res. 34, 1381 (1974)
- Metabolism of thymine in tumor tissue: the origins of beta-aminoisobutyric acid: B.S. Baliga & E. Borek; Adv. Enzyme Regul. 13, 27 (1975)
Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis: S. Landaas; Clin. Chim. Acta 64, 143 (1975)
- Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds: V. Schmieden & H. Betz; Mol. Pharmacol. 48, 919 (1995)
- Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting: C. Maisonneuve, et al.; Antivir. Ther. 9, 801 (2004)
- Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency: K. Begriche, et al.; Obesity (Silver Spring) 16, 2053 (2008)
- Effects of beta-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity: K. Begriche, et al.; Fundam. Clin. Pharmacol. 24, 269 (2010)
- In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice: A. Kittel, et al.; BBRC 430, 84 (2013)
- beta-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors: L.D. Roberts, et al.; Cell Metab. 19, 96 (2014)
- Come on BAIBA light my fire: H.L. Kammon & M. Febbraio; Cell Metab. 19, 1 (2014) (Review)
- BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice: TW. Jung, et al.; Diabetologia 58, 2096 (2015)