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AdipoGen Life Sciences
TBB
45
CHF
CHF 45.00
In stock
AG-CR1-3660-M0055 mgCHF 45.00
AG-CR1-3660-M02525 mgCHF 135.00
| Product Details | |
|---|---|
| Synonyms | 4,5,6,7-Tetrabromo-2-azabenzimidazole; Tetrabromobenzotriazole; NSC 231634; TBBt |
| Product Type | Chemical |
| Properties | |
| Formula |
C6HBr4N3 |
| MW | 434.7 |
| CAS | 17374-26-4 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Solid. |
| Solubility | Soluble in DMSO (20mg/ml). |
| InChi Key | OMZYUVOATZSGJY-UHFFFAOYSA-N |
| Smiles | BrC1=C(Br)C(Br)=C(Br)C2=C1N=NN2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- ATP/GTP-competitive cell permeable casein kinase II (CK2) inhibitor (IC50=0.9µM for rat liver. Less potently inhibits CCK2/cyclin A, GSK3β and phosphorylase kinase (IC50=15.6, 11.2 and 8.7µM, respectively). Binds to the Val66 residue of CK2 and inhibits the binding of ATP/GTP.
- Moderate DYRK1A inhibitor (IC50=4.4µM).
- Induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.
Product References
- Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'): S. Sarno, et al.; FEBS Lett. 496, 44 (2001)
- Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells: M. Ruzzene, et al.; Biochem. J. 364, 41 (2002)
- Alternative binding modes of an inhibitor to two different kinases: E. De Moliner, et al., Eur. J. Biochem. 270, 3174 (2003)
- Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole: M.A. Pagano, et al.; J. Med. Chem. 47, 6239 (2004)
- Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2: P. Zien, et al.; Biochim. Biophys. Acta 1754, 271 (2005)
- The selectivity of inhibitors of protein kinase CK2: An update: M.A. Pagano, et al.; Biochem. J. 415, 353 (2008)
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