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AdipoGen Life Sciences
CL 316,243
65
CHF
CHF 65.00
In stock
AG-CR1-3699-M0011 mgCHF 65.00
AG-CR1-3699-M0055 mgCHF 190.00
| Product Details | |
|---|---|
| Synonyms | 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino] propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H18ClNO7 . 2Na |
| MW | 419.8 . 46.0 |
| CAS | 138908-40-4 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (5mg/ml). Slightly soluble in DMSO (0.5mg/ml). |
| InChi Key | FUZBPOHHSBDTJQ-CFOQQKEYSA-L |
| Smiles | ClC1=CC=CC([C@@H](O)CN[C@H](C)CC2=CC=C(OC(C([O-])=O)(C([O-])=O)O3)C3=C2)=C1.[Na+].[Na+] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and selective β3-adrenoceptor agonist (EC50=3nM) that is >10,000-fold selective over β1 and β2.
- Antidiabetic and antiobesity agent. Causes a rapid decrease in blood glucose level in mice.
- Increases brown adipose tissue thermogenesis.
- Induces functionally active mitochondrial uncoupling protein (UCP) in white fat.
- Restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice.
Product References
- Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent: J.D. Bloom, et al.; J. Med. Chem. 35, 3081 (1992)
- Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist, in yellow KK mice: T. Yoshida, et al.; Life Sci. 54, 491 (1994)
- Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats: J. Himms-Hagen, et al.; Am. J. Physiol. 266, R1371 (1994)
- Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats: M. Ghorbani & J. Himms-Hagen; Int. J. Obes. Relat. Metab. Disord. 21, 465 (1997)
- Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans: C. Weyer, et al.; Diabetes 47, 1555 (1998)
- The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors: J.G. Baker; Br. J. Pharmacol. 144, 317 (2005)
- The effects of beta(3)-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-alpha expressions in adipose tissues of obese diabetic KKAy mice: L. Fu, et al.; Eur. J. Pharmacol. 584, 202 (2008)
- Anti diabetic effect of CL 316,243 (a β3-adrenergic agonist) by down regulation of tumour necrosis factor (TNF-α) expression: M. Ghorbani, et al.; PLoS One 7, e45874 (2012)
- The β3-adrenergic receptor is dispensable for browning of adipose tissues: J.M.A. de Jong, et al.; Am. J. Physiol. Endocrinol. Metab. 312, E508 (2017)
- Browning of white adipose tissue induced by the ß3 agonist CL-316,243 after local and systemic treatment - PK-PD relationship: W. Danysz, et al.; Biochim. Biophys. Acta 1864, 2972 (2018)
- Deconstructing adipogenesis induced by β3-adrenergic receptor activation with single-cell expression profiling: R.B. Burl, et al.; Cell Metab. 28, 300 (2018)
- NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice: F. Guo, et al.; Nature Sci. Rep. 11, 16409 (2021)
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