Monosodium urate (crystals)

CHF 105.00
In stock
AG-CR1-3950-M0022 mgCHF 105.00
AG-CR1-3950-20022 x 2 mgCHF 170.00
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Product Details
Synonyms MSU (crystals); Uric acid (crystals)
Product Type Chemical
Properties
Formula

C5H3N4O3 . Na

MW 167.1 . 23.0
CAS 1198-77-2
RTECS YU7062000
Appearance Solid crystals. Solution may appear as a slightly hazy suspension.
Solubility Not soluble in PBS. Reconstitute 2mg of MSU in 100μl PBS to obtain a 20mg/ml suspension.
Endotoxin Content <0.001EU/μg purified protein (LAL test; Lonza).
InChi Key NAFSTSRULRIERK-UHFFFAOYSA-M
Smiles [Na+].[O-]C1=NC(=O)NC2=C1NC(=O)N2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Vortex before use.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Working aliquots are stable for up to 12 months when stored at -20°C.
Documents
Protocols Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • NLRP3/NALP3 inflammasome activator. Specially crystallized and tested for biological activity.
  • Stimulates the caspase-1 activating NLRP3/NALP3 inflammasome, resulting in the production of active IL-1β and IL-18.
Product References
  1. Gout-associated uric acid crystals activate the NALP3 inflammasome: F. Martinon, et al.; Nature 440, 237 (2006)
  2. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases: M.T. Shio, et al.; PLoS Pathog. 5, e1000559 (2009)
  3. Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process: E.J. Giamarellos-Bourboulis, et al.; Ann. Rheum. Dis. 68, 273 (2009)
  4. Monosodium urate crystals in inflammation and immunity: Y. Shi, et al.; Immunol. Rev. 233, 203 (2010)
  5. RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality: L. Meng, et al.; PNAS 112, 11007 (2015)
  6. Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation: S. Suzuki, et al.; EMBO Rep.19, 89 (2018)
  7. Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release: Y. Dautova, et al.; J. Mol. Cell Cardiol. 115, 82 (2018)
  8. Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation: T. Murakami, et al.; J. Immunol. 202, 1942 (2019)
  9. Expression of a PYCARD/ASC variant lacking exon 2 in Japanese patients with palindromic rheumatism increases interleukin-1β secretion: Y. Suganuma, et al.; Asian Pac. J. Allergy Immunol. (Epub ahead of print) (2019)
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