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AdipoGen Life Sciences
(S)-CR8
290
CHF
CHF 290.00
In stock
AG-MR-C0004-M01010 mgCHF 290.00
AG-MR-C0004-M05050 mgCHF 870.00
| Product Details | |
|---|---|
| Synonyms | 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H29N7O |
| MW | 431.5 |
| CAS | 1084893-56-0 |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | HOCBJBNQIQQQGT-IBGZPJMESA-N |
| Smiles | CC[C@@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC2=CC=C(C=C2)C2=NC=CC=C2)=N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent cyclin-dependent kinase (CDK) 1, 2, 5, and 9 inhibitor [1, 2].
- Apoptosis inducer [1, 3, 5].
- Inhibits the proliferation of various cancer cell lines [1].
- Inhibits cysts formation in culture [4].
- Casein kinase 1 (CK1δ/ε) and Dyrk1A inhibitor [1].
- Down regulates expression of Mcl-1 and MYCN.
- Neuroprotective in experimental traumatic brain injury.
- Potential anti-inflammatory compound.
- Potential antidiabetic compound.
Product References
- CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008)
- Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1: N. Oumata, et al.; J. Med. Chem. 51, 5229 (2008)
- CDK inhibitors roscovitine and CR8 trigger Mcl-1 down-regulation and apoptotic cell death in neuroblastoma cells: K. Bettayeb, et al.; Genes Cancer 1, 369 (2010)
- CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD: N.O. Bukanov, et al.; Cell Cycle 11, 4040 (2012)
- CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury. S.V. Kabadi, et al.; Neurotherapeutics 9, 405 (2012)
- Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)
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