Ancell

anti-CD244 (human), mAb (ANC2B4/3B12) (preservative free)

CHF 306.00
In stock
ANC-259-820100 µgCHF 306.00
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Product Details
Synonyms Natural Killer Cell Receptor 2B4; NK Cell Activation-inducing Ligand; NAIL; NKR2B4; SLAMF4
Product Type Monoclonal Antibody
Properties
Clone ANC2B4/3B12
Isotype Mouse IgG1κ
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant soluble human CD244.
Label/Conjugates Preservative Free
Application

ELISA

Flow Cytometry

Crossreactivity Human
Specificity

Binds to a CD244 epitope that is distinct from the binding sites of clone ANC244.8 (ANC-239-020) and clone C1.7.

Purity ≥95% (SDS-PAGE)
Purity Detail Protein A purified.
Formulation 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl.
Isotype Negative Control

Mouse IgG1 Isotype Control (preservative free)

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number Q9BZW8
Declaration Manufactured by Ancell Corporation.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Avoid freeze/thaw cycles.
Keep sterile.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.

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