Ancell

anti-CD357 [GITR] (human), mAb (ANC5E3) (preservative free)

CHF 306.00

In stock

ANC-368-820100 µgCHF 306.00

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Product Details
Synonyms	GITR; Glucocorticoid-induced TNF Receptor; AITR; Activation-inducible TNF-related; Tumor Necrosis Factor Receptor Superfamily Member 18; TNFRSF18
Product Type	Monoclonal Antibody
Properties
Clone	ANC5E3
Isotype	Mouse IgG3κ
Immunogen/Antigen	Recombinant human GITR, PHA stimulated human PBL.
Label/Conjugates	Preservative Free
Application	Flow Cytometry ELISA
Crossreactivity	Human
Formulation	50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl
Isotype Negative Control	Mouse IgG3 Isotype Control (preservative free)
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by Ancell Corporation.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Glucocorticoid induced TNF receptor family related gene (GITR; AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18. GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break T cell suppression. GITR has been implicated as a regulatory mechanism in anti-parasitic immune resposes, and is involved with macrophages activation in atherosclerotic plaque formation.

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