BellBrook

PARG (human) (rec.) (His) (active) (10µg)

CHF 782.00
In stock
BBL-2285-C01010 µgCHF 782.00
More Information
Product Details
Synonyms Poly(ADP-ribose) Glycohydrolase
Product Type Protein
Properties
Source/Host Baculovirus system
Sequence

Recombinant human PARG enzyme (aa1-976) fused to a C-terminal His-tag.

Crossreactivity Human
Biological Activity

The enzyme has been thoroughly validated with Transcreener ADPR Activity Assays. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot.

MW 111.9kDa
Purity ≥80% (SDS-PAGE)
Accession Number Q86W56
Formulation Liquid. In 50mM Tris-HCl pH 7.5, 500mM NaCl, 10% glycerol, 1mM TCEP.
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. PARG plays an important role in DNA damage repair and has been seen as a potential target for anticancer therapy.

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