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BellBrook
PARG (human) (rec.) (His) (active) (10µg)
782
CHF
CHF 782.00
In stock
BBL-2285-C01010 µgCHF 782.00
| Product Details | |
|---|---|
| Synonyms | Poly(ADP-ribose) Glycohydrolase |
| Product Type | Protein |
| Properties | |
| Source/Host | Baculovirus system |
| Sequence |
Recombinant human PARG enzyme (aa1-976) fused to a C-terminal His-tag. |
| Crossreactivity | Human |
| Biological Activity |
The enzyme has been thoroughly validated with Transcreener ADPR Activity Assays. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot. |
| MW | 111.9kDa |
| Purity | ≥80% (SDS-PAGE) |
| Accession Number | Q86W56 |
| Formulation | Liquid. In 50mM Tris-HCl pH 7.5, 500mM NaCl, 10% glycerol, 1mM TCEP. |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. PARG plays an important role in DNA damage repair and has been seen as a potential target for anticancer therapy.
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