Kendomycin

CHF 90.00
In stock
BVT-0001-C100100 µgCHF 90.00
BVT-0001-C500500 µgCHF 180.00
BVT-0001-MM252.5 mgCHF 540.00
More Information
Product Details
Synonyms (-)-TAN 2162
Product Type Chemical
Properties
Formula C29H42O6
MW 486.6
CAS 183202-73-5
Source/Host Chemicals Isolated from Streptomyces violaceoruber.
Purity Chemicals ≥98% (HPLC)
Appearance Yellow powder.
Solubility Slightly soluble in methanol or DMSO.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
InChi Key HKLDUJXJTQJSEJ-OLXNOMCWSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
After reconstitution protect from light at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antibiotic.
  • Potent endothelin receptor antagonist.
  • Anti-osteoporotic.
  • Antibacterial.
  • Anticancer agent. Cytotoxic against several carcinoma cell lines (GI50<100nM). 
  • 20S proteasome inhibitor. Induces apoptosis by inhibition of chymotrypsin-like proteasome activity.
Product References
  1. Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces: H.B. Bode & A. Zeeck; J. Chem. Soc. Perkin Trans 1, 323 and 2665 (2000)
  2. Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin: Y.A. Elnakady, et al.; ChemBioChem. 8, 1261 (2007)
  3. Formal Synthesis of (−)-Kendomycin Featuring a Prins-Cyclization To Construct the Macrocycle: K.B. Bahnck & S.D. Rychnovsky; JACS 130, 13177 (2008)
  4. Interactions of the natural product kendomycin and the 20S proteasome: P. Beck, et al.; J. Mol. Biol. 426, 3108 (2014)
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