Chartreusin

CHF 150.00
In stock
BVT-0005-M0055 mgCHF 150.00
BVT-0005-M02525 mgCHF 560.00
 
More Information
Product Details
Synonyms Lambdamycin
Product Type Chemical
Properties
Formula C32H32O14
MW 640.6
Merck Index 14: 2045
CAS 6377-18-0
RTECS FL7350000
Source/Host Chemicals Isolated from Streptomyces chartreusis.
Purity Chemicals ≥98% (HPLC)
Appearance Yellow solid.
Solubility Soluble in acetone; insoluble in water.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
InChi Key PONPPNYZKHNPKZ-CIFTUGPDSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
After reconstitution protect from light at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antibiotic
  • Antitumor compound.
  • Topoisomerase II inhibitor.
  • Induces single-strand scission in DNA in the presence of reducing agents.
  • Apoptosis inducer.
  • Inhibitor of glioblastoma multiforme (GBM).
Product References
  1. Chartreusin, a new antibiotic produced by Streptomyces chartreusis, a new species: B. E. Leach, et al.; J. Am. Chem. Soc. 75, 4011 (1953)
  2. Chartreusin, a glycosidic antitumour antibiotic from Streptomyces: J.A. Beisler; Prog. Med. Chem. 19, 247 (1982) (Review)
  3. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B.H. Long; Eur. J. Cancer 14, 1985 (1993)
  4. Chartreusin, elsamicin A and related anti-cancer antibiotics: J. Portugal; Curr. Med. Chem. Anticancer Agents 3, 411 (2003) (Review)
  5. Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide: Z. Xu, et al.; Chem. Biol. 12, 579 (2005)
  6. In silico studies on marine actinomycetes as potential inhibitors for glioblastoma multiforme: P. Kirubakaran, et al.; Bioinformation 6, 100 (2011)
  7. Synthetic Remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities: N. Ueberschaar, et al.; JACS 135, 17408 (2013)
  8. Rational design of an apoptosis-inducing photoreactive DNA intercalator: N. Ueberschaar, et al.; Angew. Chem. Int. Edit. 52, 6185 (2013)
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