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BioViotica
Chartreusin
155
CHF
CHF 155.00
In stock
BVT-0005-M0055 mgCHF 155.00
| Product Details | |
|---|---|
| Synonyms | Lambdamycin |
| Product Type | Chemical |
| Properties | |
| Formula |
C32H32O14 |
| MW | 640.6 |
| Merck Index | 14: 2045 |
| CAS | 6377-18-0 |
| RTECS | FL7350000 |
| Source/Host Chemicals | Isolated from Streptomyces chartreusis. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in acetone; insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | PONPPNYZKHNPKZ-CIFTUGPDSA-N |
| Smiles | CO[C@H]1[C@@H](O)[C@@H](C)O[C@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](C)O[C@H]2OC2=CC=CC3=C2C2=C4C(C(=O)OC5=C4C(=C(C)C=C5)C(=O)O2)=C3O)[C@@H]1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at +4°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic
- Antitumor compound.
- Topoisomerase II inhibitor.
- Induces single-strand scission in DNA in the presence of reducing agents.
- Apoptosis inducer.
- Inhibitor of glioblastoma multiforme (GBM).
Product References
- Chartreusin, a new antibiotic produced by Streptomyces chartreusis, a new species: B. E. Leach, et al.; J. Am. Chem. Soc. 75, 4011 (1953)
- Chartreusin, a glycosidic antitumour antibiotic from Streptomyces: J.A. Beisler; Prog. Med. Chem. 19, 247 (1982) (Review)
- Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B.H. Long; Eur. J. Cancer 14, 1985 (1993)
- Chartreusin, elsamicin A and related anti-cancer antibiotics: J. Portugal; Curr. Med. Chem. Anticancer Agents 3, 411 (2003) (Review)
- Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide: Z. Xu, et al.; Chem. Biol. 12, 579 (2005)
- In silico studies on marine actinomycetes as potential inhibitors for glioblastoma multiforme: P. Kirubakaran, et al.; Bioinformation 6, 100 (2011)
- Synthetic Remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities: N. Ueberschaar, et al.; JACS 135, 17408 (2013)
- Rational design of an apoptosis-inducing photoreactive DNA intercalator: N. Ueberschaar, et al.; Angew. Chem. Int. Edit. 52, 6185 (2013)
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