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BioViotica
Reticulol
90
CHF
CHF 90.00
In stock
BVT-0011-C250250 µgCHF 90.00
BVT-0011-M0011 mgCHF 190.00
| Product Details | |
|---|---|
| Synonyms | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-isochromen-1-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H10O5 |
| MW | 222.2 |
| CAS | 26246-41-3 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, acetone or dimethylformamide. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | LREZRXWUEZCZRU-UHFFFAOYSA-N |
| Smiles | COC1=C(O)C2=C(C=C(C)OC2=O)C=C1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Cyclic adenosine 3',5'-monophosphate phosphodiesterase and topoisomerase I (Topo I) inhibitor.
- Antitumor compound.
- Potential antifood allergic agent. Decreased the rates of degranulation and histamine release.
Product References
- Reticulol, a new metabolic isocoumarin: L.A. Mitscher, et al.; Experientia 20, 258 (1964)
- Isocoumarins from Streptomyces mobaraensis: M.A.W. Eaton and D.W. Hutchinson; Tetrahedron Lett. 12, 1337 (1971)
- Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase: Y. Furutani, et al.; J. Antibiot. 28, 558 (1975)
- Biosynthetic studies of reticulol, an isocoumarin, by 13C-NMR spectroscopy: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1581 (1977)
- Inhibition of cyclic nucleotide phosphodiesterases by reticulol: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1587 (1977)
- Reticulol, an inhibitor of cyclic nucleotide phosphodiesterases: Y. Furutani, et al.; Agric. Biol. Chem. 41, 989 (1977)
- Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma: D.S. Lim, et al.; Chemotherapy 49, 146 (2003)
- Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma: D.S. Lim, et al.; Chemotherapy 49, 257 (2003)
- An Efficient Synthesis of 8-Hydroxy-6,7-dimethoxy-3-methylisocoumarin (6-O-methylreticulol): A. Saeed and S. Ehsan; Chem. Heterocyc. Comp. 41, 1381 (2005)
- Polyketides from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421 showed potent anti-food allergic activities: S. Niu, et al.; J. Agr. Food Chem. 14, 1369 (2018)
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