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BioViotica
Echinosporin
155
CHF
CHF 155.00
In stock
BVT-0006-M0011 mgCHF 155.00
BVT-0006-M0055 mgCHF 550.00
| Product Details | |
|---|---|
| Synonyms | NSC357683; XK 213; (1S,4aS,5S,7aS)-5-Hydroxy-8-oxo-1,4a,5,7a-tetrahydro-1,5-(epoxymethano)cyclopenta[c] pyran-3-carboxamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H9NO5 |
| MW | 223.2 |
| CAS | 79127-35-8 |
| RTECS | JW5313000 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water, methanol or dimethylformamide. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | OXSZHYWOGQJUST-PDXIVQBHSA-N |
| Smiles | [H][C@@]12C=C[C@@]3(O)C(=O)O[C@]1([H])OC(=C[C@@]23[H])C(N)=O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for at least 3 months when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Cell cycle inhibitor at the G(2)/M phase.
- Antitumor compound.
- Apoptosis inducer.
Product References
- A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterization: T. Sato, et al.; J. Antibiot. 35, 266 (1982)
- Antitumor activity of echinosporin: M. Morimoto and R. Imai; J. Antibiot. 38, 490 (1985)
- Approaches to the total synthesis of the antitumor antibiotic echinosporin: M. A. Kinsella; J. Org. Chem. 55, 105 (1990)
- Applications of an asymmetric [2 + 2]-photocycloaddition. Total synthesis of (-)-echinosporin. Construction of an advanced 11-deoxyprostaglandin intermediate: A. B. Smith; J. Am. Chem. Soc. 114, 2567 (1992)
- Biosynthesis of the antibiotic echinosporin by a novel branch of the shikimate pathway: A. Dubeler; Eur. J. Org. Chem. 2002, 983 (2002)
- Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolus: C.B. Cui, et al.; Fitoterapia 78, 238 (2007)
- A new stereocontrolled synthetic route to (-)-echinosporin from D-glucose via padwa allenylsulfone [3 + 2]-anionic cycloadditive elimination: J.T. Flasz, et al.; Org. Lett. 14, 3024 (2012)
- Interaction of marine streptomyces compounds with selected cancer drug target proteins by in silico molecular docking studies: A.R. Lankapalli & K. Kannabiran; Interdiscipl. Sci. Comput. Life Sci. 5, 37 (2013)
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