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BioViotica
Rubiginone B2
160
CHF
CHF 160.00
In stock
BVT-0026-M0011 mgCHF 160.00
| Product Details | |
|---|---|
| Synonyms | (+)-Rubiginone B2; X-14881C; 8-O-Methyl-ochramycinone |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H16O4 |
| MW | 320.3 |
| CAS | 130548-10-6 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO, methanol, acetone or dichloromethane. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | ZUCWNLVDTXGGSU-JTQLQIEISA-N |
| Smiles | O=C1C2=C(C(C(C[C@@H](C)C3)=O)=C3C=C2)C(C4=CC=CC(OC)=C41)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Angucyclinone antibiotic.
- Antibacterial and antitumor agent.
- Potentiates the cytotoxicity of vincristine.
- Antimalarial agent.
Product References
- Microbial products XI. Five novel metabolites related to benz[a]anthracene from an unidentified actinomycete designated X-14881: H. Maehr, et al.; J. Antibiot. 35, 1627 (1982)
- Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity: M. Oka, et al.; J. Antibiot. 43, 967 (1990)
- Absolute configuration of the rubiginones and photo-induced oxidation of the C1 hydroxyl of the antibiotics to a ketone: M. Oka, et al.; Tetrahed. Lett. 31, 7473 (1990)
- Angucycline group antibiotics: J. Rohr & R. Thiericke; Nat. Prod. Rep. 9, 103, (1992)
- New biologically active rubiginones from Streptomyces sp.: C. Puder, et al.; J. Antibiot. 53, 329 (2000)
- Angucyclinone Antibiotics: Total Syntheses of YM-181741, (+)-Ochromycinone, (+)-Rubiginone B2, Tetrangomycin and MM-47755: K.P. Kaliappan & V. Ravikumar; J. Org. Chem. 72, 6116 (2007)
- Saccharosporones A, B and C, cytotoxic antimalarial angucyclinones from Saccharopolyspora sp. BCC 21906: C. Boonlarppradab, et al.; J. Antibiot. 66, 305 (2013)
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