Rubiginone B2

CHF 175.00
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BVT-0026-M0011 mgCHF 175.00
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Product Details
Synonyms (+)-Rubiginone B2; X-14881C; 8-O-Methyl-ochramycinone
Product Type Chemical
Properties
Formula

C20H16O4

MW 320.3
CAS 130548-10-6
Source/Host Chemicals Isolated from Streptomyces sp.
Purity Chemicals ≥98% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO, methanol, acetone or dichloromethane.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
InChi Key ZUCWNLVDTXGGSU-JTQLQIEISA-N
Smiles O=C1C2=C(C(C(C[C@@H](C)C3)=O)=C3C=C2)C(C4=CC=CC(OC)=C41)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
After reconstitution protect from light at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
  • Angucyclinone antibiotic.
  • Antibacterial and antitumor agent.
  • Potentiates the cytotoxicity of vincristine.
  • Antimalarial agent.
Product References
  1. Microbial products XI. Five novel metabolites related to benz[a]anthracene from an unidentified actinomycete designated X-14881: H. Maehr, et al.; J. Antibiot. 35, 1627 (1982)
  2. Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity: M. Oka, et al.; J. Antibiot. 43, 967 (1990)
  3. Absolute configuration of the rubiginones and photo-induced oxidation of the C1 hydroxyl of the antibiotics to a ketone: M. Oka, et al.; Tetrahed. Lett. 31, 7473 (1990)
  4. Angucycline group antibiotics: J. Rohr & R. Thiericke; Nat. Prod. Rep. 9, 103, (1992)
  5. New biologically active rubiginones from Streptomyces sp.: C. Puder, et al.; J. Antibiot. 53, 329 (2000)
  6. Angucyclinone Antibiotics: Total Syntheses of YM-181741, (+)-Ochromycinone, (+)-Rubiginone B2, Tetrangomycin and MM-47755: K.P. Kaliappan & V. Ravikumar; J. Org. Chem. 72, 6116 (2007)
  7. Saccharosporones A, B and C, cytotoxic antimalarial angucyclinones from Saccharopolyspora sp. BCC 21906: C. Boonlarppradab, et al.; J. Antibiot. 66, 305 (2013)
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