MAPTAM

CHF 102.00
In stock
CDX-B0292-M01010 mgCHF 102.00
CDX-B0292-M02525 mgCHF 230.00
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Product Details
Synonyms 5,5'-Dimethyl-BAPTA-AM; 1,2-Bis(2-amino-5-methylphenoxy) ethane; 1,2-Bis(2-amino-5-methylphenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl) ester
Product Type Chemical
Properties
Formula C36H44N2O18
MW 792.74
CAS 147504-94-7
Source/Host Chemicals Synthetic.
Purity Chemicals ≥94% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in DMSO, DMF, acetonitrile, ethyl acetate or chloroform.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key HEOJVQZWOLQUDR-UHFFFAOYSA-N
Smiles CC1=CC(OCCOC2=CC(C)=CC=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

MAPTAM is a cell permeable intracellular Ca2+ chelator that can be loaded non-invasive into cells by incubation. MAPTAM itself does not bind calcium, but once inside the cell is converted into it's derivative Dimethyl-BAPTA by cytoplasmic esterases. This type of calcium chelators are commonly used to form calcium buffers with well-defined calcium concentrations. By injecting the chelators into cells or by incubating cells with the AM ester form of the chelators, one can control the cytosolic calcium concentration, an important means to study the roles of calcium. Key advantages of these calcium chelators include relative insensitivity toward intracellular pH change and fast release of calcium. Recent studies have shown that BAPTA derivative might have microtubule disruptive activity (unrelated to it's calcium chelating activity) and should be used with caution in studies of cytoskeleton-related cell functions.

Product References

(1) Biochemistry 19, 2396 (1980) | (2) R.Y. Tsein; Nature 290, 527 (1981) | (3) J.B. Lefkowith, et al.; J. Immunol. 149, 1729 (1992) | (4) K.A. Birch, et al.; J. Cell Biol. 118, 1501 (1992) | (5) E. Poch, et al.; Biochem. J. 290, 617 (1993) | (6) J.M. Dubinsky; Neurosci. Lett. 150, 129 (1993) | (7) T. Tiffert & V.L. Lew; J. Physiol. 505, 403 (1997) | (8) J.R. Wu-Wong, et al.; Clin. Sci. 103 Suppl.48, 418S (2002) | (9) A. Furuta, et al.; Endocr. J. 56, 235 (2009) | (10) R. Chen, et al.; Microb. Pathog. 83-84, 29 (2015)

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