FURA 2-AM

CHF 153.00
In stock
CDX-F0014-M0011 mgCHF 153.00
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Product Details
Synonyms FURA-2 acetoxymethyl ester; FURA-2 pentakis(acetoxymethyl) ester
Product Type Chemical
Properties
Formula C44H47N3O24
MW 1001.87
CAS 108964-32-5
Source/Host Chemicals Synthetic.
Purity Chemicals ≥95% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key VPSRLGDRGCKUTK-UHFFFAOYSA-N
Smiles O=C(OCOC(C)=O)C1=CN=C(O1)C2=CC3=C(O2)C=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(OCCOC4=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C=CC(C)=C4)=C3
Shipping and Handling
Shipping AMBIENT
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

The fluorescent probe FURA 2/AM is a membrane-permeable derivative of the calcium chelator FURA 2. Inside cells, FURA 2/AM is rapidly hydrolyzed by cytoplasmic esterases to FURA 2, which remains within the cell. Non-invasive, intracellular calcium indicator that is UV light-excitable. Fluorescent Ca2+ indicator, selective for Ca2+ over other divalent cations Mg2+, Zn2+, Fe2+ and Mn2+. FURA 2/AM is used to determine calcium concentrations in many cellular systems, including: cardiac myocytes, vascular smooth muscle cells and medullary collecting tubules. Spectral properties in the presence of low calcium concentrations (λex = 362nm, λem = 512nm) differ from those during high calcium conditions (λex = 335nm, λem = 505nm). FURA 2 is preferred for ratio-imaging microscopy, in which it is more practical to change excitation wavelengths than emission wavelengths. Spectral Data: λex 355nm; λem 495nm in 0.1 M Tris pH 8.0.

Product References

(1) G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3440 (1985) | (2) I. Maruyama, et al.; FEBS Lett. 220, 89 (1987) | (3) M.E. Janconi, et al.; J. Cell Biol. 110, 1555 (1990) | (4) Y. Schwartz, et al.; Endocrinology 131, 772 (1992) | (5) G.H. Rao, et al.; Biochem. Med. Metab. Biol. 47, 226 (1992) | (6) M.J.Davis, et al.; Am. J. Physiol. 263, H1292 (1992) | (7) M.J. Davis, et al.; Am. J. Physiol. 263, H1292 (1992) | (8) M.L. Field, et al.; Cell Calcium. 16, 87 (1994) | (9) R.W. Sabnis; Handbook of biological dyes and stains (2010)

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