CHF 162.00
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CDX-F0014-M0011 mgCHF 162.00
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Product Details
Synonyms FURA-2 acetoxymethyl ester; FURA-2 pentakis(acetoxymethyl) ester
Product Type Chemical
Formula C44H47N3O24
MW 1001.87
CAS 108964-32-5
Source/Host Chemicals Synthetic.
Purity Chemicals ≥95% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Shipping and Handling
Shipping AMBIENT
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

The fluorescent probe FURA 2/AM is a membrane-permeable derivative of the calcium chelator FURA 2. Inside cells, FURA 2/AM is rapidly hydrolyzed by cytoplasmic esterases to FURA 2, which remains within the cell. Non-invasive, intracellular calcium indicator that is UV light-excitable. Fluorescent Ca2+ indicator, selective for Ca2+ over other divalent cations Mg2+, Zn2+, Fe2+ and Mn2+. FURA 2/AM is used to determine calcium concentrations in many cellular systems, including: cardiac myocytes, vascular smooth muscle cells and medullary collecting tubules. Spectral properties in the presence of low calcium concentrations (λex = 362nm, λem = 512nm) differ from those during high calcium conditions (λex = 335nm, λem = 505nm). FURA 2 is preferred for ratio-imaging microscopy, in which it is more practical to change excitation wavelengths than emission wavelengths. Spectral Data: λex 355nm; λem 495nm in 0.1 M Tris pH 8.0.

Product References

(1) G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3440 (1985) | (2) I. Maruyama, et al.; FEBS Lett. 220, 89 (1987) | (3) M.E. Janconi, et al.; J. Cell Biol. 110, 1555 (1990) | (4) Y. Schwartz, et al.; Endocrinology 131, 772 (1992) | (5) G.H. Rao, et al.; Biochem. Med. Metab. Biol. 47, 226 (1992) | (6) M.J.Davis, et al.; Am. J. Physiol. 263, H1292 (1992) | (7) M.J. Davis, et al.; Am. J. Physiol. 263, H1292 (1992) | (8) M.L. Field, et al.; Cell Calcium. 16, 87 (1994) | (9) R.W. Sabnis; Handbook of biological dyes and stains (2010)

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