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Chemodex
7-Benzyloxy-4-trifluoromethycoumarin
272
CHF
CHF 272.00
In stock
CDX-B0299-M05050 mgCHF 272.00
CDX-B0299-M250250 mgCHF 815.00
| Product Details | |
|---|---|
| Synonyms | BFC |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H11F3O3 |
| MW | 320.3 |
| CAS | 220001-53-6 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (NMR) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | WVKLERKKJXUPIK-UHFFFAOYSA-N |
| Smiles | O=C1C=C(C(F)(F)F)C2=C(C=C(OCC3=CC=CC=C3)C=C2)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
7-Benzyloxy-4-trifluoromethylcoumarin is a fluorescent substrate for cytochrome P450 family members CYP1A2, CYP3A4 and potentially others. Has been used in high-throughput screens in fluorometric p450 activity assays and is metabolized to the fluorescent metabolite 7-Hydroxy-4-trifluoromethylcoumarin (HFC) with λex=410nm; λem=530nm.
Product References
(1) A.B. Renwick, et al.; Xenobiotica 30, 955 (2000) | (2) A.B. Renwick, et al.; Xenobiotica 31, 861 (2001) | (3) K.K. Khan & J.R. Halpert; Chem. Res. Toxicol. 15, 806 (2002) | (4) V. Zlabek & G. Zamaratskaia; Animal 6, 633 (2012) | (5) Y.T. Ung, et al.; High-Throughput 7, 29 (2018) (Review) | (6) H. Raunio, et al.; Int. J. Mol. Sci. 21, 4708 (2020) (Review)
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