DL-3-Hydroxyisobutyric acid sodium salt
|Synonyms||(±)-Sodium β-hydroxyisobutyrate; (±)-β-HIBA-Na; 3-Hydroxy-2-methylpropionic acid sodium salt; Sodium 3-hydroxy-2-methylpropionate|
|Purity Chemicals||≥96% (GC)|
|Appearance||White to off-white powder.|
|Solubility||Soluble in water (50mg/ml). Soluble in DMSO (5mg/ml, ultrasonication needed).|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.
(1) S. Landaas; Clin. Chim. Acta 64, 143 (1975) | (2) J.W. Hawes, et al.; Methods Enzymol. 324, 218 (2000) | (3) F.J. Loupatty, et al.; Am. J. Hum. Genet. 80, 195 (2007) | (4) C.M. Viegas, et al.; Int. J. Dev. Neurosci. 26, 293 (2008) | (5) R.J. Wanders, et al.; J. Inherit. Metab. Dis. 35, 5 (2012)