IL-10 (human):Fc (human) (rec.)

CHF 285.00
In stock
CHI-HF-21010-C01010 µgCHF 285.00
CHI-HF-21010-C05050 µgCHF 495.00
CHI-HF-21010-50105 x 10 µgCHF 990.00
More Information
Product Details
Synonyms Interleukin-10; Cytokine Sythesis Inhibitory Factor; CSIF
Product Type Protein
Properties
Source/Host CHO cells
Sequence

The extracellular domain of human IL-10 (aa 19-178) is fused to the N-terminus of the Fc region of human IgG1.

Crossreactivity Human
Purity ≥98% (SDS-PAGE)
Endotoxin Content <0.06EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute 10µg vial in 100µl sterile water.
Reconstitute 50µg vial in 50µl sterile water.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

NCBI reference NP_000563.1: IL-10 (human)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

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