Chimerigen

IL-10 (human):Fc (human) (rec.)

CHF 260.00

In stock

CHI-HF-21010-C01010 µgCHF 260.00

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Product Details
Synonyms	Interleukin-10; Cytokine Sythesis Inhibitory Factor; CSIF
Product Type	Protein
Properties
Source/Host	CHO cells
Sequence	The extracellular domain of human IL-10 (aa 19-178) is fused to the N-terminus of the Fc region of human IgG1.
Crossreactivity	Human
Purity	≥98% (SDS-PAGE)
Endotoxin Content	<0.06EU/μg protein (LAL test; Lonza).
Reconstitution	Reconstitute 10µg vial in 100µl sterile water. Reconstitute 50µg vial in 50µl sterile water. Add 1X PBS to the desired protein concentration.
Formulation	Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.)
Other Product Data	NCBI reference NP_000563.1: IL-10 (human)
Declaration	Manufactured by Chimerigen.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

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