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Chimerigen
IL-10 (human) (rec.) (His)
250
CHF
CHF 250.00
In stock
CHI-HR-20010-C01010 µgCHF 250.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-10; Cytokine Synthesis Inhibitory Factor; CSIF |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human IL-10 (aa 19-178) is fused at the N-terminus to a His-tag. |
| Crossreactivity | Human |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg protein (LAL test; Lonza). |
| Reconstitution | Reconstituted in sterile H2O not less than 100μg/ml, which can then be further diluted in other aqueous solutions. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS (pH 7.4). |
| Other Product Data | NCBI reference NP_000563.1: IL-10 (human) |
| Declaration | Manufactured by Chimerigen. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
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