IL-10Rα (human):Fc (human) (rec.)

CHF 435.00
In stock
CHI-HF-21010RA-C05050 µgCHF 435.00
More Information
Product Details
Synonyms Interleukin-10 Receptor alpha; IL-10RA; CD210; IL-10R1; CDw210a;
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

The extracellular domain of human IL-10Rα (aa 22-235) is fused to the N-terminus of the Fc region of human IgG1.

Crossreactivity Human
Biological Activity

Measured by its ability to inhibit IL-10-dependent proliferation of MC/9- 2 mouse mast cells.

MW ~70kDa (SDS-PAGE)
Purity ≥98% (SDS-PAGE)
Endotoxin Content <5EU/mg protein (LAL test; Lonza).
Reconstitution Reconstitute 50µg vial with 50 µl sterile water to a concentration of 1mg/ml.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

NCBI reference AAH28082.1: IL-10Rα (human)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

CD210, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD210 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD210 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

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