IL-10Rα (human):Fc (human) (rec.)
|Synonyms||Interleukin-10 Receptor alpha; IL-10RA; CD210; IL-10R1; CDw210a;|
|Source/Host||HEK 293 cells|
The extracellular domain of human IL-10Rα (aa 22-235) is fused to the N-terminus of the Fc region of human IgG1.
Measured by its ability to inhibit IL-10-dependent proliferation of MC/9- 2 mouse mast cells.
|Endotoxin Content||<5EU/mg protein (LAL test; Lonza).|
Reconstitute 50µg vial with 50 µl sterile water to a concentration of 1mg/ml.
Add 1X PBS to the desired protein concentration.
|Formulation||Lyophilized from 0.2μm-filtered solution in PBS.|
|Protein Negative Control|
|Other Product Data||
NCBI reference AAH28082.1: IL-10Rα (human)
|Declaration||Manufactured by Chimerigen.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Avoid freeze/thaw cycles.|
Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
CD210, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD210 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD210 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.