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Innaxon
Lipodisq™ Styrene:Maleic Acid Universal Copolymer with pH-Selector
As low as
300
CHF
CHF 300.00
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IAX-700-205-M100100 mgCHF 300.00
IAX-700-205-M500500 mgCHF 725.00
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Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | SMALP; uSMA |
| Product Type | Chemical |
| Properties | |
| Formula |
C12H10O4Na2 |
| MW |
5,500 (based on weight) 2,100 (based on number) |
| CAS | 26762-29-8 |
| Purity Chemicals | ≥98% |
| Appearance | White powder. |
| Solubility | Soluble in water, and buffer solutions (pH 4.50-8.50) to allow the formulation of a proprietary, thermostable, aqueous lipid nanoparticle. |
| Reconstitution | Avoid the use of buffers with divalent ions such as Ca or Mg or pH <3.5 or >5.5, which can cause P(SMA) precipitation or interfere with SMA-Lipid Particle fornulation or stability. |
| Formulation | Lipodisq™ are nanosized lipid-based discoidal particles that can be manufactured with P(SMA)/ SMALP and lipids such as DMPC (14:0 PC) (DMPC: IAX-700-400) to incorporate hydrophobic, poorly water-soluble active compounds. |
| Declaration | Manufactured by Innaxon. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet: Our product description may differ slightly from the original manufacturer's product datasheet. Lipodisq™ technology is covered by one or more of the following patents owned by Malvern Cosmeceutics Limited: AU2006253886, CA2611144, CN101184473B, EP1890675, GB2426703, IN261468, JP5142898, US8623414 and WO/2021/005340A1 pending. The purchaser is licensed under those patents to use these assemblies for the purpose of research and development only, but not for the purpose of delivery of agents for clinical use to humans or veterinary use to animals for therapeutic, diagnostic or prophylactic purposes, which uses are specifically prohibited. |
| Smiles | |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice |
Do not freeze. Keep sterile. Avoid skin and eye contact. |
| Use/Stability | Stable for at least 3 years after receipt when stored at +20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
- A nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilized by a chaperone molecular annulus.
- Components are batch-tested for Lipodisq™ formation using buffer systems available, which are tested for nano-formulated drug analysis by Dynamic Light Scattering (DLS). These buffer solutions are endotoxin-tested and sterile.
Enables membrane proteins (MP) to be reconstituted within phospholipid membrane mimics without the use of mediating detergent. Nanodiscs formed from SMA are also referred to as styrene maleic acid lipid particles (SMALP). SMA-lipid particles are formed by directly extracting membrane proteins either from native cellular membranes (giving native nanodiscs) or from an intermediary MP-reconstituted synthetic membrane system to ultimately form self-assembled discoidal nano-structures of a general diameter of 10-12 nm.
- uSMA requires only a single polymer grade to be used, avoids the need to select several SMA grades that each operate only over a narrow pH range.
- uSMA can be tailored to operate over a wide pH range 4.5-8.5 by simple addition of standard quantities of pH-Selector™
- uSMA is insensitive to presence of divalent cations, Ca2+(<10mM) and Mg2+ (<30mM), suitable for use with ion pores, ABC transporters and ion sensitive GPCR assemblies
- uSMA can be modified to form larger particles, reducing direct interactions between the polymer chaperone and membrane‑bound proteins
The ability of SMA to create monodisperse nanodiscs covering a range of particle sizes facilitates the reconstitution of oligomeric MPs and MP complexes for analysis by various methods including fluorescence microscopy, NMR and single-particle cryo-EM.
Product-specific References
- Reconstitution of membrane proteins: a GPCR as an example: A.D. Goddard, et al.; Methods Enzymol. 556, 405 (2015)
- The styrene-maleic acid copolymer: a versatile tool in membrane research: J.M. Doerr, et al.; Eur. Biophys. J. 45, 3 (2016)
- From polymer chemistry to structural biology: The development of SMA and related amphipathic polymers for membrane protein extraction and solubilization: J.F. Bada Juarez, et al.; Chem. Phys. Lipids. 221, 167 (2019)
- Effects of charged lipids on the physicochemical and biological properties of lipid-styrene-maleic acid copolymer discoidal particles: M. Tanakaa, et al.; Biochim. Biophys. Acta. Biomembr. 1862, 183209 (2020)
- Physicochemical Characterization, Toxicity and In Vivo Biodistribution Studies of a Discoidal, Lipid-Based Drug Delivery Vehicle: Lipodisq Nanoparticles Containing Doxorubicin: M.L. Torgersen, et al.; J. Biomed. Nanotechnol. 16, 41 (2020)
- Understanding the Structural Pathways for Lipid Nanodisc Formation: How Styrene Maleic Acid Copolymers Induce Membrane Fracture and Disc Formation: V.A. Bjornestad, et al.; Langmuir 37, 6178 (2021)
- Applications of Synthetic Polymer Discoidal Lipid Nanoparticles to Biomedical Research: M. Tanaka; Chem. Pharm. Bull. 70, 507 (2022)
- Mechanisms of Formation, Structure, and Dynamics of Lipoprotein Discs Stabilized by Amphiphilic Copolymers: A Comprehensive Review: P.S. Orekhov, et al.; Nanomaterials 12, 361 (2022)
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