JaICA

anti-Acrolein [ACR], mAb (5F6)

CHF 2'070.00

In stock

JAI-MAR-100N100 µgCHF 2'070.00

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Product Details
Product Type	Monoclonal Antibody
Properties
Clone	5F6
Isotype	Mouse IgG1κ
Immunogen/Antigen	ACR-modified keyhole-lympet hemocyanine.
Application	Immunohistochemistry: Recommended concentration is 0.5-1μg/mL on paraffin sections.
Crossreactivity	All Human
Specificity	Recognizes ACR-modified proteins (especially FDP-lysine type derivatives).
Purity Detail	Protein A purified.
Formulation	Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.
Isotype Negative Control	Mouse IgG1 Isotype Control
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by JaICA.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 3 years after receipt when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Acrolein (ACR) is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidasecatalyzed amino acid oxidation. ACR is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with ACR and lysine residue leads to the formation of numerous numbers of adducts, such as formyl-dehydropiperidino-lysine (FDP-lysine) type derivative.

Product References

Protein-bound acrolein: Potential markers for oxidativestress: K. Uchida, et al.; PNAS 95, 4882 (1998)
Protein-bound acrolein: A novel markers of oxidativestress in Alzheimer's Disease: Y. Noel, et al.; J. Neurochem. 72, 751 (1999)

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