JaICA

anti-Malondialdehyde [MDA], mAb (1F83)

CHF 830.00

In stock

JAI-MMD-030N30 µgCHF 830.00

Figure 1: Immunohistochemical staining of MDA-modified protein in atherosclerotic aorta using anti-MDA, mAb (1F83).

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Product Details
Product Type	Monoclonal Antibody
Properties
Clone	1F83
Isotype	Mouse IgG2aλ
Immunogen/Antigen	MDA-modified keyhole-lympet hemocyanine.
Application	Immunohistochemistry: Recommended concentration is 0.5-1μg/mL on paraffin sections.
Crossreactivity	All Human
Specificity	Recognizes MDA-modified proteins (especially DHP-lysine).
Purity Detail	Protein A purified.
Formulation	Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.
Isotype Negative Control	Mouse IgG2a Isotype Control
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by JaICA.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 3 years after receipt when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Malondialdehyde (MDA) is one of the major aldehyde derive from lipid peroxidation. MDA is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with MDA and lysine residue leads to the formation of numerous numbers of adducts, such as dihydropyridine-lysine (DHP-lysine) type derivative.

Product References

Immunochemical detection of a lipofuscin-like fluorophore derivered from malondialdehyde and lysine: S. Yamada, et al.; J. Lipid Res. 42, 1187 (2001)
A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis: F. Yao, et al.; Nature Comm. 12, 7333 (2021)
Synergy of intermittent fasting and ferroptosis inhibition dampens ‘cytokine storm’: H. Wang, et al.; Res. Square doi.org/10.21203/rs.3.rs-1697205/v1 ahead of print (2022)
Membranes and deoxyribonucleic acid of hippocampal neurons damage due to low-density polyethylene microplastics in blood of Wistar rats: Y. Sincihu, et al.; Int. J. Health Sci. 6, 3490 (2022)
Wistar Rats Hippocampal Neurons Response to Blood Low-Density Polyethylene Microplastics: A Pathway Analysis of SOD, CAT, MDA, 8-OHdG Expression in Hippocampal Neurons and Blood Serum Aβ42 Levels: Y. Sincihu, et al.; Neuropsych. Dis. Treat. 19, 73 (2023)
Detection of Ferroptosis in Patient-Derived Tumor Models: W. Zhang & Y. Wang; Methods Mol. Biol. 2712, 187 (2023)
Pyruvate kinase M2 nuclear translocation regulate ferroptosis-associated acute lung injury in cytokine storm: H. Wang, et al.; Res. Square doi.org/10.21203/rs.3.rs-3507704/v1 (2023)
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition: W. Cui, et al.; Nature Cell Biol. 26, 124 (2024)

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