RevMab

anti-VISTA, Rabbit Monoclonal (RM503)

CHF 459.00

In stock

REV-31-1395-00-R100100 µlCHF 459.00

Figure 1: Immunohistochemical staining of formalin-fixed and paraffin embedded human breast cancer tissue sections using anti-VISTA Rabbit Monoclonal Antibody (RM503) at 1:100 dilution.

Specifications / Handling

More Information
Product Details
Synonyms	B7-H5; V-type Immunoglobulin Domain-containing Suppressor of T Cell Activation; Platelet Receptor Gi24; Stress-induced Secreted Protein-1; Sisp-1; V-set Domain-containing Immunoregulatory Receptor
Product Type	Recombinant Antibody
Properties
Clone	RM503
Isotype	Rabbit IgG
Source/Host	Rabbit
Immunogen/Antigen	A peptide corresponding to residues near the C-terminus of human VISTA.
Application	Immunohistochemistry (IHC): 1:100-1:200 dilution Western Blot (WB): 1:1000-1:2000 dilution
Crossreactivity	Human Mouse Rat
Specificity	This antibody reacts to human, mouse or rat VISTA.
Purity	Protein A purified.
Purity Detail	Protein A affinity purified from an animal origin-free culture supernatant.
Concentration	N/A
Formulation	Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control	Rabbit IgG
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Accession Number	Q9H7M9
Declaration	Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping	BLUE ICE
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.

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