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CX-6258
227
CHF
CHF 227.00
In stock
SYN-1182-M0011 mgCHF 227.00
SYN-1182-M0055 mgCHF 383.00
SYN-1182-M01010 mgCHF 551.00
SYN-1182-M05050 mgCHF 1'646.00
SYN-1182-M100100 mgCHF 2'568.00

Product Details | |
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Synonyms | CX6258 |
Product Type | Chemical |
Properties | |
Formula | C26H24ClN3O3 |
MW | 461.9 |
CAS | 1202916-90-2 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: PKC - PKCα | Kinase Group: STE | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | KGBPLKOPSFDBOX-CJLVFECKSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS |
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Product Specification Sheet | |
Datasheet |
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CX6258 is a potent inhibitor of Pim-1, Pim-2 and Pim-3 with IC(50) values of 5, 25 and 16nM, respectively.
Product References
- CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy: A. Siddiqui-Jain, et al.; Cancer Res. 70, 10288 (2010)
- Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor: M. Haddach, et al.; ACS Med. Chem. Lett. 3, 135 (2011)