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SynKinase
CX-6258
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | CX6258 |
| Product Type | Chemical |
| Properties | |
| Formula | C26H24ClN3O3 |
| MW | 461.9 |
| CAS | 1202916-90-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PKC - PKCα | Kinase Group: STE | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | KGBPLKOPSFDBOX-CJLVFECKSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
CX6258 is a potent inhibitor of Pim-1, Pim-2 and Pim-3 with IC(50) values of 5, 25 and 16nM, respectively.
Product References
- CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy: A. Siddiqui-Jain, et al.; Cancer Res. 70, 10288 (2010)
- Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor: M. Haddach, et al.; ACS Med. Chem. Lett. 3, 135 (2011)
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