TRAIL-R2 (human):Fc (human) (rec.)

CHF 220.00
In stock
AG-40B-0071-C05050 µgCHF 220.00
AG-40B-0071-30503 x 50 µgCHF 440.00
More Information
Product Details
Synonyms DR5; TNFRSF 10B; CD262; Tumor Necrosis Factor Receptor Superfamily Member 10B; TRAIL Receptor 2
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence The extracellular domain of human TRAIL-R2 (aa 52-212) is fused to the Fc portion of human IgG1.
Crossreactivity Human
Mouse
Specificity Binds to human and mouse TRAIL.
Biological Activity Blocks human or mouse TRAIL activity in a concentration of 1-10μg/ml.
MW ~50kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration 1mg/ml after reconstitution.
Reconstitution Reconstitute with 50μl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data UniProt link O14763: TRAIL-R2 (human) (precursor)
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

TRAIL-R2 (DR5; CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-κB.

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.