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AdipoGen Life Sciences
Ferutinin (high purity)
55
CHF
CHF 55.00
In stock
AG-CN2-0007-M0011 mgCHF 55.00
AG-CN2-0007-M0055 mgCHF 160.00
AG-CN2-0007-M01010 mgCHF 250.00
| Product Details | |
|---|---|
| Synonyms | 4-Oxy-6-(4-oxybenzoyloxy)dauc-8,9-en; Tefestrol |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H30O4 |
| MW | 358.5 |
| CAS | 41743-44-6 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, acetone, dichloromethane or ethyl acetate. |
| Identity | Determined by 1H-NMR |
| InChi Key | CYSHNJQMYORNJI-YUVXSKOASA-N |
| Smiles | [H][C@@]12[C@H](CC(C)=CC[C@@]1(C)CC[C@@]2(O)C(C)C)OC(=O)C1=CC=C(O)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. Protect from moisture and oxygen. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent, naturally occuring non-steroid estrogenic compound.
- Tool to promote mitochondrial calcium overload and to promote calcium-dependent opening of the mitochondrial permeability transition pore (mPTP) [1, 3, 4].
- Strong agonist for estrogen receptor (ER)α and agonist/antagonist for ERβ [2, 8].
- Calcium ionophoretic [4, 11]
- Apoptosis modulator [4].
- Antiproliferative [5, 7].
- Increases nitric oxide synthase activity and phosphoinositides breakdown in nervous tissue [6].
- Shows aphrodisiac and anti-sexual impotence activities [6].
- Anti-osteoporotic. Prevents osteoporosis caused by severe estrogen deficiency [9].
- Modest AChE inhibitor [10].
Product References
- Ionophoretic properties of ferutinin: M.V. Zamaraeva, et al.; Cell Calcium 22, 235 (1997)
- Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta: K. Ikeda, et al.; BBRC 291, 354 (2002)
- Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells: A.Y. Abramov & M.R. Duchen; Cell Calcium 33, 101 (2003)
- Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line: A. Macho, et al.; Biochem. Pharmacol. 68, 875 (2004)
- Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines: F. Poli, et al.; Phytother. Res. 19, 152 (2005)
- Ferutinin stimulates nitric oxide synthase activity in median eminence of the rat: T. Colman-Saizarbitoria, et al.; J. Ethnopharmacol. 106, 327 (2006)
- Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines: R. Alkhatib, et al.; Phytochemistry 69, 2979 (2008)
- The phytoestrogen ferutinin affects female sexual behavior modulating ERalpha expression in the hypothalamus: P. Zanoli, et al.; Behav. Brain Res. 199, 283 (2009)
- Influence of ferutinin on bone metabolism in ovariectomized rats. II: role in recovering osteoporosis: M. Ferretti, et al.; J. Anat. 217, 4 (2010)
- Identification of non-alkaloid acetylcholinesterase inhibitors from Ferulago campestris (Besser) Grecescu (Apiaceae): S. Dall'acqua, et al.; Fitoterapia 81, 1208 (2010)
- Ferutinine structure: A.I. Saidkhodjaev, et al.; Chem. Nat. Comp. 1, 28 (1973)
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