AdipoGen Life Sciences

Purpuromycin

CHF 200.00

In stock

AG-CN2-0317-M0055 mgCHF 200.00

AG-CN2-0317-M02525 mgCHF 700.00

More Information
Product Details
Product Type	Chemical
Properties
Formula	C₂₆H₁₈O₁₃
MW	538.4
CAS	53969-01-0
Source/Host Chemicals	Isolated from Actinoplanes sp.
Purity Chemicals	≥95% (HPLC)
Appearance	Red powder.
Solubility	Soluble in DMSO, aqueous acetonitrile or ethanol.
Identity	Determined by ¹H-NMR and MS.
InChi Key	VGXVKHPGBHVPMW-GWQKEKGPSA-N
Smiles	O[C@H]1C[C@@]2(OC3=C(O)C(C(OC(C(OC)=O)=C4)=O)=C4C=C13)CC5=C(O)C(C(C=C(OC)C6=O)=O)=C6C(O)=C5O2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light. Protect from light when in solution.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Rubromycin antibiotic.
Antibacterial, antifungal and anti-protozoal agent. Active against Gram-positive bacteria, Gram-negative bacteria and fungi.
Telomerase inhibitor (IC₅₀=3µM).
Protein synthesis inhibitor. Binds tRNAs with high affinity and specifically inhibits aminoacyl-tRNA formation consequent inhibition of protein synthesis in these microorganisms.
Inhibits of all tRNA synthetases. Effectively inhibits bacterial translation and translation in eukaryotic cells.
Modest inhibitor of retroviral reverse transcriptase.

Product References

Purpuromycin, a new antibiotic isolated from Actinoplanes ianthinogenes N. sp.: C. Coronelli, et al.; J. Antibiot. 27, 161 (1974)
Structure determination of purpuromycin, a new antibiotic: M.R: Bardone, et al.; Tetrahedron 30, 2747 (1974)
Effect of the antibiotic purpuromycin on cell-free protein-synthesizing systems: F. Rambelli, et al.; Biochem. J. 259, 307 (1989)
Mechanism of action of purpuromycin: P. Landini, et al.; Biochem. J. 284, 47 (1992)
Chemical modifications of the antibiotic purpuromycin: A. Trani, et al.; Farmaco 48, 637 (1993)
In-vitro activity of purpuromycin and MDL 63,604 against microorganisms that cause vaginitis and vaginosis: B.P. Goldstein, et al.; J. Antimicrob. Chemother. 36, 1061 (1995)
Purpuromycin: an antibiotic inhibiting tRNA aminoacylation: S. Kirillov, et al.; RNA 3, 905 (1997)
Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39, 5995 (2000)
Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products: D.J. Atkinson & M.A. Brimble; Nat. Prod. Rep. 32, 811 (2015)

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