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AdipoGen Life Sciences
Umifenovir . hydrochloride
60
CHF
CHF 60.00
In stock
AG-CR1-3718-M01010 mgCHF 60.00
AG-CR1-3718-M05050 mgCHF 180.00
AG-CR1-3718-M250250 mgCHF 540.00
| Product Details | |
|---|---|
| Synonyms | Arbidol; ARB |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H25BrN2O3S . HCl |
| MW | 477.4 . 36.5 |
| CAS | 131707-23-8 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in ethanol (10mg/ml), DMSO (15mg/ml) or DMF (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | OMZHXQXQJGCSKN-UHFFFAOYSA-N |
| Smiles | BrC1=C(O)C(CN(C)C)=C(C(C(OCC)=O)=C(CSC2=CC=CC=C2)N3C)C3=C1.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
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Umifenovir is a broad-spectrum, indole-based antiviral compound that blocks viral fusion with target membranes, prohibiting viral entry into cells. Fusion between the viral envelope (surrounding the viral capsid) and the cell membrane of the target cell is inhibited. This prevents viral entry to the target cell and therefore protects it from infection.
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Umifenovir targets a common critical step for viral replication and therefore it is effective against numerous viruses, including influenza A, B and C and hepatitis B and C. Recent studies indicate that umifenovir also has in vitro effectiveness at preventing entry of Zika virus, Ebola virus, Tacaribe arenavirus and human herpes virus 8 in mammalian cell cultures.
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Clinical studies against SARS-CoV-2 are ongoing to test its efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19).
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Besides its antiviral action, it has been reported to produce an immunomodulatory response by inducing interferon production and stimulating the phagocytic function of macrophages. It also displays anti-inflammatory activity.
Product References
- Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection: Y.S. Boriskin, et al.; Virol. J. 3, 56 (2006)
- Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol: E.I. Pecheur, et al.; Biochemistry 46, 6050 (2007)
- Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo: L. Shi, et al.; Arch. Virol. 152, 1447 (2007)
- Arbidol: A broad-spectrum antiviral compound that blocks viral fusion: Y.S. Boriskin, et al.; Curr. Med. Chem. 15, 997 (2008) (Review)
- Antiviral activity of Arbidol against Coxsackie virus B5 in vitro and in vivo: Q. Zhong, et al.; Arch. Virol. 154, 601 (2009)
- Membranotropic effects of arbidol, a broad anti-viral molecule, on phospholipid model membranes: J. Villalain; J. Phys. Chem. B 114, 8544 (2010)
- Targeting cell entry of enveloped viruses as an antiviral strategy: E. Teissier, et al.; Molecules 16, 221 (2010) (Review)
- Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol: E. Teissier, et al.; PLoS One 6, e15874 (2011)
- Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection: Q. Liu, et al.; Acta Pharmacol. Sin. 34, 1075 (2013)
- Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking: J. Blaising, et al.; Antiviral Res. 100, 215 (2013)
- Arbidol as a broad-spectrum antiviral: an update: J. Blaising, et al.; Antiviral Res. 107, 84 (2014) (Review)
- The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses: E.I. Pecheur, et al.; J. Virol. 90, 3086 (2016)
- Antiviral activity of arbidol hydrochloride against herpes simplex virus I in vitro and in vivo: M.K. Li, et al.; Int. J. Antimicrob. Agents 51, 98 (2018)
- The Antiviral Drug Arbidol Inhibits Zika Virus: S.L. Fink, et al.; Sci. Rep. 8, 8989 (2018)
- Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses: J. Haviernik, et al.; Viruses 10, E184 (2018)
- Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses: C.E. Hulseberg, et al.; J. Virol. 93, e02185 (2019)
- Discovering drugs to treat coronavirus disease 2019 (COVID-19): L. Dong, et al.; Drug Discov. Ther. 14, 58 (2020)
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