Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Nexturastat B
80
CHF
CHF 80.00
In stock
AG-CR1-3902-M0011 mgCHF 80.00
AG-CR1-3902-M0055 mgCHF 240.00
| Product Details | |
|---|---|
| Synonyms | 4-((1-Butyl-3-(1H-indazol-6-yl)ureido)methyl)-N-hydroxybenzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H23N5O3 |
| MW | 381.4 |
| CAS | 1648893-33-7 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off white solid. |
| Solubility | Soluble in DMSO, methanol or ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | SDIVUCIYBAWAQP-UHFFFAOYSA-N |
| Smiles | CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC1=CC2=C(C=NN2)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50=3nM). Displays high selectivity over HDAC1 (300-fold).
- More soluble analog of nexturastat A (Prod. No. AG-CR1-3901).
- Suppresses cell proliferation of B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78 at a slightly lower concentration than nexturastat A.
- Shown to be effective in a mouse melanoma tumor xenograft model, increasing tumor volumes in vivo.
- Down-regulates the production of IL-10.
- HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Product References
- Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation: K.V. Woan, et al.; Mol. Oncol. 9, 1447 (2015)
- Exploration of some new HDAC inhibitors for cancer and CNS diseases: A.P. Kozikowski; 13th Annual Discovery on Target (presentation) (2015)
Related Products
