MBIMPH

CHF 200.00
In stock
AG-CR1-3907-M0011 mgCHF 200.00
AG-CR1-3907-M0055 mgCHF 800.00
More Information
Product Details
Synonyms N-Hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide
Product Type Chemical
Properties
Formula

C16H15N3O2

MW 281.3
CAS 1392835-53-8
Purity Chemicals ≥98% (HPLC)
Appearance Off-white solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
InChi Key SGZCUGGIJNIVPP-UHFFFAOYSA-N
Smiles CC1=NC2=C(C=CC=C2)N1CC1=CC=C(C=C1)C(=O)NO
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM).
  • Induces cellular α-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport.
  • Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (Prod. No. AG-CR1-3900).
  • HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Product References
  1. Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)
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