AdipoGen Life Sciences

MBIMPH F-Analog 2

CHF 200.00
In stock
AG-CR1-3909-M0011 mgCHF 200.00
AG-CR1-3909-M0055 mgCHF 800.00
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Product Details
Synonyms MBIMPH Fluorinated Analog 2; 4-((6-Fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-N-hydroxybenzamide
Product Type Chemical


MW 299.3
Purity Chemicals ≥95% (HPLC)
Appearance Light brown solid.
Solubility Soluble in DMSO, ethanol or methanol.
Identity Determined by 1H-NMR.
Smiles CC1=NC2=C(C=C(F)C=C2)N1CC1=CC=C(C=C1)C(=O)NO
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM).
  • Induces cellular α-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport.
  • Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900).
  • HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Product References
  1. Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)
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