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AdipoGen Life Sciences
PMPH
160
CHF
CHF 160.00
In stock
AG-CR1-3905-M0011 mgCHF 160.00
AG-CR1-3905-M0055 mgCHF 640.00
| Product Details | |
|---|---|
| Synonyms | 4-((1H-Pyrazol-1-yl)methyl)-N-hydroxybenzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H11N3O2 |
| MW | 217.2 |
| CAS | 1392835-64-1 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, methanol or ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | DUGDSZFLAKVUEC-UHFFFAOYSA-N |
| Smiles | ONC(=O)C1=CC=C(CN2C=CC=N2)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =11nM). Displays high selectivity over HDAC1 (IC50=1.5µM).
- Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular α-tubulin hyperacetylation.
- HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Product References
- Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)
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