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AdipoGen Life Sciences
MBIMPH F-Analog 1 . hydrochloride
200
CHF
CHF 200.00
In stock
AG-CR1-3908-M0011 mgCHF 200.00
AG-CR1-3908-M0055 mgCHF 800.00
| Product Details | |
|---|---|
| Synonyms | MBIMPH Fluorinated Analog 1; 3-Fluoro-N-hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H14FN3O2 . HCl |
| MW | 299.3 . 36.5 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, ethanol, methanol or water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | NWMOSGPUNITEFR-UHFFFAOYSA-N |
| Smiles | Cl.CC1=NC2=C(C=CC=C2)N1CC1=C(F)C=C(C=C1)C(=O)NO |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =3nM). Displays high selectivity over all other HDACs (IC50=0.03-20µM).
- Induces cellular α-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport.
- Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900).
- HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Product References
- Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)
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