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Ancell
anti-FOXP3 (human), mAb (ANCFX2D7)
306
CHF
CHF 306.00
In stock
ANC-333-020100 µgCHF 306.00
| Product Details | |
|---|---|
| Synonyms | Forkhead Box Protein P3; Scurfin; IPEX, JM2 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | ANCFX2D7 |
| Isotype | Mouse IgG1κ |
| Immunogen/Antigen | Recombinant human FOXP3. |
| Application |
ELISA |
| Crossreactivity | Human |
| Specificity |
Recognizes human FOXP3. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein A-affinity purified. |
| Formulation | 50mM Sodium phosphate pH7.5, 100mM Potassium chloride, 150mM NaCl, 0.5mg/ml Gentamicin sulfate (as preservative). |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Ancell Corporation. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.
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