anti-FOXP3 (human), mAb (ANCFX2D7) (FITC)
|Synonyms||Forkhead Box Protein P3; Scurfin; IPEX, JM2|
|Product Type||Monoclonal Antibody|
|Immunogen/Antigen||Recombinant human FOXP3.|
Recognizes human FOXP3.
|Purity Detail||Protein A-affinity purified.|
|Formulation||50mM Sodium phosphate pH7.5, 100mM Potassium chloride, 150mM NaCl, 5% glycerol, 0.2%BSA, 0.04% sodium azide (preservative).|
|Isotype Negative Control|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Declaration||Manufactured by Ancell Corporation.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
Avoid freeze/thaw cycles.
Protect from light.
|Use/Stability||Stable for at least 1 year after receipt when stored at +4°C.|
|Product Specification Sheet|
FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.