anti-FOXP3 (human), mAb (ANCFX2D7) (R-PE)

Specifications / Handling

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Product Details
Synonyms	Forkhead Box Protein P3; Scurfin; IPEX, JM2
Product Type	Monoclonal Antibody
Properties
Clone	ANCFX2D7
Isotype	Mouse IgG1κ
Immunogen/Antigen	Recombinant human FOXP3.
Label/Conjugates	R-PE
Application	ELISA Flow Cytometry
Crossreactivity	Human
Specificity	Recognizes human FOXP3.
Purity	≥95% (SDS-PAGE)
Purity Detail	Protein A-affinity purified.
Formulation	50mM Sodium phosphate pH7.5, 500mM Potassium chloride, 150mM NaCl, 15% glycerol, 0.2%BSA, 0.04% sodium azide (as preservative).
Isotype Negative Control	Mouse IgG1 Isotype Control (R-PE)
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by Ancell Corporation.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Do not freeze. Protect from light.
Use/Stability	Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.

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