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Chemodex
Fluo-3 AM
264
CHF
CHF 264.00
In stock
CDX-F0033-M0011 mgCHF 264.00
CDX-F0033-M01010 mgCHF 2'144.00
| Product Details | |
|---|---|
| Synonyms | Fluo-3 AM |
| Product Type | Chemical |
| Properties | |
| Formula | C51H50Cl2N2O23 |
| MW | 1129.85 |
| CAS | 121714-22-5 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥90% (TLC) |
| Appearance | Dark red powder. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | PTPUOMXKXCCSEN-UHFFFAOYSA-N |
| Smiles | CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=C(C=C1OCCOC1=C(C=CC(C)=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C1=C2C=C(Cl)C(=O)C=C2OC2=CC(OCOC(C)=O)=C(Cl)C=C12 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Ca2+-indicator fluo-3 for use with visible-light excitation sources in flow cytometry and confocal laser-scanning microscopy. Since about 1996, fluo-3 has also been extensively used in cell-based high-throughput screening assays for drug discovery. Fluo-3 AM is essentially nonfluorescent until it is hydrolyzed intracellularly and/or in the presence of Ca2+. The green-fluorescent emission (~525 nm) of Ca2+-bound fluo-3 is conventionally detected using optical filter sets designed for fluorescein (FITC). As prepared by Minta, Kao and Tsien, fluo-3 was originally reported to undergo an ~40-fold increase in fluorescence upon binding Ca2+.
Product References
(1) T. Toyofuku et al.; Geochem., Geophys., Geosyst. 9(5) | (2008) | (2) D.M. Plank et al.; Meth. Cell Sc. 25(3-4), 123 (2004) | (3) P. Vandenberghe et al.; J. Immun.Meth. 127, 197 (1990) | (4) J.P.Y. Kao et al.; J. Biol. Chem. 264, 8179 (1989)
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