Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Trichostatin A (synthetic)
110
CHF
CHF 110.00
In stock
AG-CN2-0523-M0011 mgCHF 110.00
AG-CN2-0523-M0055 mgCHF 330.00
| Product Details | |
|---|---|
| Synonyms | TSA; A300; R-(E,E)-7-(4-(Dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H22N2O3 |
| MW | 302.4 |
| Merck Index | 14: 9649 |
| CAS | 58880-19-6 |
| Source/Host Chemicals | Synthetic. Originally isolated from Streptomyces hygroscopicus. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, ethanol, methanol, dimethyl formamide, acetonitrile or chloroform. Insoluble in water or hexane. |
| Identity | Determined by 1H-NMR. |
| InChi Key | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| Smiles | C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic, antifungal and antiprotozoal agent.
- Potent and reversible, cell permeable inhibitor of class I and II histone deacetylases (HDACs).
- Anticancer, immunosuppressive, antifibrogenic compound.
- Induces apoptosis and cell growth arrest at both G1 and G2/M phases. Also inactivates mitotic spindle checkpoint.
- Enhances the efficacy of anticancer agents that target DNA.
- Downregulates DNA methyltransferase DNMT1 and affects DNA methylation.
- Telomerase inhibitor.
- Smooth muscle cell proliferation inhibitor.
- Anti-inflammatory and inhibits osteoclastogenesis and bone resorption.
- Promotes either self-renewal or differentiation of embryonic stem cells.
Product References
- A new antifungal antibiotic, trichostatin: N. Tsuji, et al.; J. Antibiot. (Tokyo) 29, 1 (1976)
- Screening for new antitrichomonal substances of microbial origin and antitrichomonal activity of trichostatin A: K. Otoguro, et al.; J. Antibiot. (Tokyo) 41, 461 (1988)
- Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A: M. Yoshida, et al.; J. Biol. Chem. 265, 17174 (1990)
- Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase: I. Takahashi, et al.; J. Antibiot. (Tokyo) 49, 453 (1996)
- Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells: B. Eickhoff, et al.; Biol. Chem. 381, 107 (2000)
- Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo: D.M. Vigushin, et al.; Clin. Cancer Res. 7, 971 (2001)
- Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts: K. Rombouts, et al.; Exp. Cell Res. 278, 184 (2002)
- The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses: J.M. Moreira, et al.; BMC Cancer 3, 30 (2003)
- Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells: M.S. Roh, et al.; Apoptosis 9, 583 (2004)
- Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells: T. Chiba, et al.; Oncology 66, 481 (2004)
- A histone deacetylase inhibitor, trichostatin A, enhances radiosensitivity by abrogating G2/M arrest in human carcinoma cells: I.A. Kim, et al.; Cancer Res. Treat. 37, 122 (2005)
- Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents: M. Dowling, et al.; Cancer Biol. Ther. 4, 197 (2005)
- Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1): H. Okamoto, et al.; J. Atheroscler. Thromb. 13, 183 (2006)
- Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells: H.J. Woo, et al.; Exp. Mol. Pathol. 82, 77 (2007)
- Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells: R. Januchowski, et al.; Cancer Lett. 246, 313 (2007)
- Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis: C. Habold, et al.; J. Cell Mol. Med. 12, 607 (2008)
- Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages: S.B. Han & J.K. Lee; Arch. Pharm. Res. 32, 613 (2009)
- Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL: H.N. Kim, et al.; Eur. J. Pharmacol. 623, 22 (2009)
- Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis: W.P. Chen, et al.; Rheumatol. Int. 31, 1325 (2011)
- Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming: A. Kretsovali, et al.; Stem Cells Int. 2012, 1 (2012)
- HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents: M. McMahon, et al.; PLoS One 9, e114055 (2014)
Related Products
