AdipoGen Life Sciences

Daptomycin

CHF 70.00

In stock

AG-CN2-0542-M02525 mgCHF 70.00

AG-CN2-0542-M100100 mgCHF 190.00

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Product Details
Synonyms	LY146032; Dapcin; Cubicin; Cidecin
Product Type	Chemical
Properties
Formula	C₇₂H₁₀₁N₁₇O₂₆
MW	1620.7
CAS	103060-53-3
RTECS	HB5626000
Source/Host Chemicals	Isolated from Streptomyces sp.
Purity Chemicals	≥95% (HPLC)
Appearance	Off-white to pale yellow powder.
Solubility	Soluble in water (25mg/ml), DMSO (50mg/ml) or methanol (5mg/ml).
Identity	Determined by ¹H-NMR.
InChi Key	DOAKLVKFURWEDJ-RWDRXURGSA-N
Smiles	O=C(O[C@H](C)[C@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC(CCCCCCCCC)=O)CC1=CNC2=C1C=CC=C2)=O)CC(N)=O)=O)=O)C(NC3)=O)[C@H](CC(C4=C(N)C=CC=C4)=O)NC([C@@H](NC([C@@H](CO)NC(CNC([C@H](CC(O)=O)NC([C@@H](C)NC([C@H](CC(O)=O)NC([C@@H](NC3=O)CCCN)=O)=O)=O)=O)=O)=O)[C@H](C)CC(O)=O)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Daptomycin, a naturally occurring cyclic lipopeptide, is a calcium-dependent antibiotic.
It exhibits potent bacteriocidal activity against most Gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE.
Daptomycin disrupts the bacterial plasma membrane function, which results in membrane depolarization consequently leading to inhibition of protein, DNA and RNA synthesis, essential for cell division and cell wall synthesis.

Product References

In-vitro activity of vancomycin, teicoplanin, daptomycin, ramoplanin, MDL 62873 and other agents against staphylococci, enterococci and Clostridium difficile: A. Bartoloni, et al.; J. Antimicrob. Chemother. 26, 627 (1990)
Development of daptomycin for Gram-positive infections: F.P. Tally & M.F. DeBruin; J. Antimicrob. Chemother. 46, 523 (2000)
Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin; D. Jung, et al.; Chem. Biol. 11, 949 (2004)
Daptomycin: A lipopeptide antibiotic for the treatment of serious Gram-positive infections: J.N. Steenbergen, et al.; J. Antimicrob. Chemother. 55, 283 (2005)
The action mechanism of daptomycin: S.C. Taylor & M. Palmer; Bioorg. Med. Chem. 24, 6253 (2016) (Review)
More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin: D.A. Gray & M. Wenzel; Antibiotics 9, 17 (2020) (Review)
DAPTOMYCIN, its membrane-active mechanism vs. that of other antimicrobial peptides: H.W. Huang; Biochim. Biophys. Acta Biomembr. 1862, 183395 (2020) (Review)
The Antibiotic Peptide Daptomycin Functions by Reorganizing the Membrane: A. Pokorny & P.F. Almeida; J. Membr. Biol. 254, 97 (2021) (Review)

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