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AdipoGen Life Sciences
Z-Leu-Leu-Leu-AMC
50
CHF
CHF 50.00
In stock
AG-CP3-0019-M0011 mgCHF 50.00
AG-CP3-0019-M0055 mgCHF 150.00
| Product Details | |
|---|---|
| Synonyms | Z-LLL-AMC; Proteasome Substrate I |
| Product Type | Chemical |
| Properties | |
| Formula |
C36H48N4O7 |
| MW | 648.8 |
| Sequence |
Z-Leu-Leu-Leu-7-amido-4-methylcoumarin |
| CAS | 152015-61-7 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Solid lyophilized powder. |
| Solubility | Soluble in DMSO. |
| Other Product Data |
Use: Reaction conditions will need to be optimized for each specific application. |
| InChi Key | MBZJQSNQQJWUBH-DTXPUJKBSA-N |
| Smiles | CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC1=CC=C2C(C)=CC(=O)OC2=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Protect from light. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome.
- Excitation: 345nm. Emission: 445nm.
- This substrate is useful for inhibitor screening and kinetic analysis.
Product References
- The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome: M.E. Figueiredo-Pereira, et al.; J. Biol. Chem. 271, 16455 (1996)
- Transforming growth factor-beta inhibition of proteasomal activity: a potential mechanism of growth arrest: L. Tadlock, et al.; Am. J. Physiol. Cell Physiol. 285, C277 (2003)
- Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis: V. Gama, et al.; Exp. Cell. Res. 312, 488 (2006)
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