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AdipoGen Life Sciences
Z-Leu-Leu-Glu-AMC
55
CHF
CHF 55.00
In stock
AG-CP3-0022-M0011 mgCHF 55.00
AG-CP3-0022-M0055 mgCHF 150.00
| Product Details | |
|---|---|
| Synonyms | Z-LLE-AMC; Proteasome Substrate II |
| Product Type | Chemical |
| Properties | |
| Formula |
C35H44N4O9 |
| MW | 664.8 |
| Sequence |
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin |
| CAS | 348086-66-8 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Solid lyophilized powder. |
| Solubility | Soluble in DMSO. |
| Other Product Data |
Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Typical concentrations range from 10-100µM. |
| InChi Key | FOYHOBVZPWIGJM-KCHLEUMXSA-N |
| Smiles | CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NC1=CC=C2C(C)=CC(=O)OC2=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Protect from light. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (PGPH) (caspase-like) activity of the 20S proteasome.
- Excitation: 380nm. Emission: 460nm.
Product References
- 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor: T.L. Chang, et al.; Planta Med. 76, 987 (2010)
- Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit: J. Blackburn, et al.; Biochem. J. 430, 461 (2010)
- The protease DDI2 regulates NRF1 activation in response to cadmium toxicity: S.T. Ribeiro, et al.; iScience 25, 105227 (2022)
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