AdipoGen Life Sciences

Z-Leu-Leu-Glu-AMC

CHF 55.00
In stock
AG-CP3-0022-M0011 mgCHF 55.00
AG-CP3-0022-M0055 mgCHF 150.00
More Information
Product Details
Synonyms Z-LLE-AMC; Proteasome Substrate II
Product Type Chemical
Properties
Formula

C35H44N4O9

MW 664.8
Sequence

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin

CAS 348086-66-8
Purity Chemicals ≥95% (HPLC)
Appearance Solid lyophilized powder.
Solubility Soluble in DMSO.
Other Product Data

Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Typical concentrations range from 10-100µM.

InChi Key FOYHOBVZPWIGJM-KCHLEUMXSA-N
Smiles CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NC1=CC=C2C(C)=CC(=O)OC2=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (PGPH) (caspase-like) activity of the 20S proteasome.
  • Excitation: 380nm. Emission: 460nm.
Product References
  1. 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor: T.L. Chang, et al.; Planta Med. 76, 987 (2010)
  2. Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit: J. Blackburn, et al.; Biochem. J. 430, 461 (2010)
  3. The protease DDI2 regulates NRF1 activation in response to cadmium toxicity: S.T. Ribeiro, et al.; iScience 25, 105227 (2022)
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