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AdipoGen Life Sciences
Z-Val-Leu-Arg-AMC
150
CHF
CHF 150.00
In stock
AG-CP3-0027-M0055 mgCHF 150.00
AG-CP3-0027-M02525 mgCHF 590.00
| Product Details | |
|---|---|
| Synonyms | Z-VLR-AMC . TFA |
| Product Type | Chemical |
| Properties | |
| Formula |
C35H47N7O7 . C2HF3O2 |
| MW | 677.8 . 114.0 |
| Sequence |
Z-Val-Leu-Arg-7-amido-4-methylcoumarin |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or DMF (both 10mg/ml). |
| Other Product Data |
Use: We recommend to make a 20mM stock solution in DMSO for further use. |
| InChi Key | CQGZNXISWTZIAZ-BYCMOFKSSA-N |
| Smiles | O=C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC([NH3+])=N)C(NC1=CC=C(OC(C=C2C)=O)C2=C1)=O)=O)=O)OCC3=CC=CC=C3.FC(F)(C([O-])=O)F |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Proteasome subunit α type-1 (Macropain) substrate used for assaying the trypsin-like activity of the 20S proteasome.
- Cysteine proteinase falcipain-2 and falcipain-3 (malarial hemoglobinases) substrate.
- Cathepsin S substrate.
- Hydrolysis of this fluorogenic peptide substrate is monitored by observing fluorescence at an Excitation of 345nm and Emission at 445nm.
Product References
- Purification and characterization of a high molecular weight proteinase (macropain) from human erythrocytes: M.J. McGuire & G.N. DeMartino; Biochim. Biophys. Acta 873, 279 (1986)
- Preliminary studies on cysteine and serine proteinase activities in inflamed human gingiva using different 7-amino-4-trifluoromethyl coumarin substrates and protease inhibitors: S.W. Cox & B.M. Eley; Arch. Oral Biol. 32, 599 (1987)
- Purification and characterization of a protein inhibitor of the 20S proteasome (macropain): M. Chu-Ping, et al.; Biochim. Biophys. Acta 1119, 303 (1992)
- New specific assays for tonin and tissue kallikrein activities in rat submandibular glands. Assays reveal differences in the effects of sympathetic and parasympathetic stimulation on proteinases in saliva: D.K. Shori, et al.; Biochem. Pharmacol. 43, 1209 (1992)
- Functional Expression of Falcipain, a Plasmodium falciparum Cysteine Proteinase, Supports Its Role as a Malarial Hemoglobinase: F. Salas, et al.; Infect. Immun. 63, 2120 (1995)
- Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3: P.S. Sijwali, et al.; Biochem. J. 360, 481 (2001)
- Variably modulated gating of the 26S proteasome by ATP and polyubiquitin: X. Li & G.N. DeMartino; Biochem. J. 421, 397 (2009)
- Human Cysteine Cathepsins Are Not Reliable Markers of Infection by Pseudomonas aeruginosa in Cystic Fibrosis: C. Naudin, et al.; PLoS One 6, e25577 (2011)
- Development of Potent and Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors: J. Almaliti, et al.; Chemistry ahead of print (2023)
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