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AdipoGen Life Sciences
Rifamycin PR-3
120
CHF
CHF 120.00
In stock
AG-CN2-0335-M01010 mgCHF 120.00
AG-CN2-0335-M05050 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | 3'-(Methoxycarbonyl)-1',2'-dimethyl-rifamycin II; NCI 143-458; NCI 143458 |
| Product Type | Chemical |
| Properties | |
| Formula |
C43H54N2O13 |
| MW | 806.9 |
| CAS | 21288-98-2 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥94% (HPLC) |
| Appearance | Yellow to orange powder. |
| Solubility | Soluble in DMSO, aqueous acetonitrile or ethanol. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | ZFTSGTXASLVDRX-STQZBDMOSA-N |
| Smiles | OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O2)OC)OC(C)=O)O)=O)C3=C(N(C)C(C)=C3C(OC)=O)C4=C5C(O[C@@]2(C)C5=O)=C(C)C(O)=C41 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Ansamycin antibiotic.
- Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
- Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Product References
- Rifamycin antibiotics: inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts: S.S. Yang, et al.; J. Natl. Cancer Inst. 49, 7 (1972)
- Rifamycin Derivatives Strongly Inhibiting RNA>DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses: C. Gurgo, et al.; J. Natl. Cancer Inst. 49, 61 (1972)
- Reverse transcriptase, RNA tumour virus transformation and derivatives of rifamycin SV: R.C. Ting, et al.; Nat. New Biol. 236, 163 (1972)
- Interaction between murine type-C virus RNA-directed DNA polymerases and rifamycin derivatives: A.M. Wu & R.C. Gallo; Biochim. Biophys. Acta 340, 419 (1974)
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