Rifamycin PR-14

CHF 150.00
In stock
AG-CN2-0334-M01010 mgCHF 150.00
AG-CN2-0334-M05050 mgCHF 600.00
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Product Details
Synonyms NCI 143-462; NSC 143462; BRN 5402462; Rifamycin PR 14; 3'-Acetyl-1',2'-dimethyl-rifamycin II
Product Type Chemical


MW 790.9
CAS 21240-38-0
Source/Host Chemicals Semisynthetic.
Purity Chemicals ≥98% (HPLC)
Appearance Yellow to orange powder.
Solubility Soluble in DMSO, aqueous acetonitrile or ethanol.
Identity Determined by 1H-NMR and MS.
Smiles OC1=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@@H](C)[C@@H]([C@H](C)[C@H](/C=C/O2)OC)OC(C)=O)O)=O)C3=C(N(C)C(C)=C3C(C)=O)C4=C5C(O[C@@]2(C)C5=O)=C(C)C(O)=C41
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from light when in solution.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Ansamycin antibiotic.
  • Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
  • Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Product References
  1. Rifamycin antibiotics: inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts: S.S. Yang, et al.; J. Natl. Cancer Inst. 49, 7 (1972)
  2. Rifamycin Derivatives Strongly Inhibiting RNA>DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses: C. Gurgo, et al.; J. Natl. Cancer Inst. 49, 61 (1972)
  3. Isolation and characterization of human DNA-dependent RNA polymerase: M.-J. Tsai & G.F Saunders; Biochim. Biophys. Acta 366, 61 (1974)
  4. Effect of the rifamycin dimers on the activities of nucleic acid polymerases from various sources. Relation between lipophily and toxicity: M. Talpaert-Borle, et al.; J. Antibiot. 28, 580 (1975)
  5. Structure-Activity Relationships and DNA Polymerases From Normal and Specificity of Inhibition of Leukemia Cells of Man and From Simian Sarcoma Virus by Rifamycin Derivatives: R.A. CiCioccio & B.I.S. Srivastava; J. Natl. Cancer Inst. 61, 1187 (1978)
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